-
Article
Open AccessHuman biodistribution and radiation dosimetry for the tau tracer [18F]Florzolotau in healthy subjects
Tau pathology plays a crucial role in neurodegeneration diseases including Alzheimer’s disease (AD) and non-AD diseases such as progressive supranuclear palsy. Tau positron emission tomography (PET) is an in-v...
-
Article
Detection of Alzheimer’s disease using ECD SPECT images by transfer learning from FDG PET
To develop a practical method to rapidly utilize a deep learning model to automatically extract image features based on a small number of SPECT brain perfusion images in general clinics to objectively evaluate...
-
Article
Open AccessAuthor Correction: 18F-THK5351 PET imaging in patients with progressive supranuclear palsy: associations with core domains and diagnostic certainty
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open Access18F-THK5351 PET imaging in patients with progressive supranuclear palsy: associations with core domains and diagnostic certainty
The associations of 18F-THK5351 tau positron emission tomography (PET) findings with core domains of progressive supranuclear palsy (PSP) and its diagnostic certainty have yet to be fully elucidated. The 18F-THK5...
-
Article
Open AccessInvestigation of reactive astrogliosis effect on post-stroke cognitive impairment
The aim of this study is to investigate the associations between post-stroke cognitive impairment (PSCI) severity and reactive astrogliosis (RA) extent on normalized 18F-THK-5351 positron-emission tomography (PET...
-
Article
Open AccessPlasma amyloid assay as a pre-screening tool for amyloid positron emission tomography imaging in early stage Alzheimer’s disease
Due to the high cost and high failure rate of ascertaining amyloid positron emission tomography positivity (PET+) in patients with earlier stage Alzheimer’s disease (AD), an effective pre-screening tool for am...
-
Article
Open AccessPlasmon-Activated Water Reduces Amyloid Burden and Improves Memory in Animals with Alzheimer’s Disease
With the great extension of the human lifespan in recent times, many aging diseases have inevitably followed. Dementia is one of the most-commom neurodegenerative aging diseases, in which inflammation-related ...
-
Article
Open AccessAuthor Correction: Plasma Aβ analysis using magnetically-labeled immunoassays and PET 18F-florbetapir binding in non-demented patients with major depressive disorder
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
-
Article
Open AccessA comparison between spinal cord infarction and neuromyelitis optica spectrum disorders: Clinical and MRI studies
This study aims to investigate the clinical features and magnetic resonance imaging (MRI) findings in patients with spinal cord infarction (SCI) and neuromyelitis optica spectrum disorders (NMOSDs). Over a per...
-
Article
Open AccessQuantitative study of 18F-(+)DTBZ image: comparison of PET template-based and MRI based image analysis
[18F]9-fluoropropyl-(+)-dihydrotetrabenazine (18F-(+)DTBZ) is a recently developed PET tracer to investigate the vesicular monoamine transporter type 2 (VMAT2) activity in measuring dopaminergic degeneration in v...
-
Article
Open AccessCharacteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease
The change in hypometabolism affects the regional links in the brain network. Here, to understand the underlying brain metabolic network deficits during the early stage and disease evolution of AD (Alzheimer d...
-
Article
Open AccessFocused Ultrasound-Induced Blood-Brain Barrier Opening Enhances GSK-3 Inhibitor Delivery for Amyloid-Beta Plaque Reduction
Alzheimer’s disease (AD) is a neurodegenerative disease that is the leading cause of age-related dementia. Currently, therapeutic agent delivery to the CNS is a valued approach for AD therapy. Unfortunately, t...
-
Article
Open AccessVisualization of ischemic stroke-related changes on 18F-THK-5351 positron emission tomography
The 18F-THK-5351 radiotracer has been used to detect the in vivo tau protein distribution in patients with tauopathy, such as Alzheimer’s disease and corticobasal syndrome. In addition, 18F-THK-5351 can also moni...
-
Article
Open AccessPlasma Aβ analysis using magnetically-labeled immunoassays and PET 18F-florbetapir binding in non-demented patients with major depressive disorder
An increased level of brain amyloid deposition and a decreased level of cerebral spinal fluid (CSF) Aβ42 are currently considered reliable biomarkers of Alzheimer’s disease (AD); however, the usefulness of pla...
-
Article
[18F]FP-(+)-DTBZ PET study in a lactacystin-treated rat model of Parkinson disease
Lactacystin has been used to establish rodent models of Parkinson disease (PD), with cerebral α-synuclein inclusions. This study evaluated the uptake of [18F]9-fluoropropyl-(+)-dihydrotetrabenazine ([18F]FP-(+)-D...
-
Article
Open AccessEveryday cognition scales are related to cognitive function in the early stage of probable Alzheimer’s disease and FDG-PET findings
We applied the Everyday Cognition (ECog) scale in normal aging adults and patients with Alzheimer’s disease (AD) to investigate associations between neuropsychological tests and neuroimaging markers. A total o...
-
Article
Open AccessBeta-amyloid deposition in patients with major depressive disorder with differing levels of treatment resistance: a pilot study
Lack of treatment response in patients with late-life depression is common. The role of brain beta-amyloid (Aβ) deposition in treatment outcome in subjects with late-life depression remains unclear. The presen...
-
Article
Imaging characteristic of dual-phase 18F-florbetapir (AV-45/Amyvid) PET for the concomitant detection of perfusion deficits and beta-amyloid deposition in Alzheimer’s disease and mild cognitive impairment
We investigated dual-phase 18F-florbetapir (AV-45/Amyvid) PET imaging for the concomitant detection of brain perfusion deficits and beta-amyloid deposition in patients with Alzheimer’s disease (AD) and amnestic m...
-
Article
Beta-amyloid deposition and cognitive function in patients with major depressive disorder with different subtypes of mild cognitive impairment: 18F-florbetapir (AV-45/Amyvid) PET study
The objective of this study was to evaluate the amyloid burden, as assessed by 18F-florbetapir (AV-45/Amyvid) positron emission tomography PET, in patients with major depressive disorder (MDD) with different subt...
-
Article
Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography
The literature suggests that a history of depression is associated with an increased risk of develo** Alzheimer’s disease (AD). The aim of this study was to examine brain amyloid accumulation in patients wit...
