33 Result(s)

Article

Proteomic features of soft tissue tumours in adolescents and young adults

Adolescents and young adult (AYA) patients with soft tissue tumours including sarcomas are an underserved group with disparities in treatment outcomes.

Yuen Bun Tam, Kaan Low, Hari PS, Madhumeeta Chadha… in Communications Medicine (2024)

Article

Pharmacological EZH2 inhibition combined with retinoic acid treatment promotes differentiation and apoptosis in rhabdomyosarcoma cells

Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impaired myogenic differentiation. Despite intensive treatment, 5-year survival for patient...

Eleanor O’Brien, Carmen Tse, Ian Tracy, Ian Reddin, Joanna Selfe… in Clinical Epigenetics (2023)

Article

The proteomic landscape of soft tissue sarcomas

Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited treatment options. Here we undertake comprehensive proteomic profiling of tumour specimens from 321 STS patients representing 11...

Jessica Burns, Christopher P. Wilding, Lukas Krasny, **xuan Zhu… in Nature Communications (2023)

Article

Imaging features of primary sites and metastatic patterns of angiosarcoma

Angiosarcomas are rare, aggressive soft tissue sarcomas originating from endothelial cells of lymphatic or vascular origin and associated with a poor prognosis. The clinical and imaging features of angiosarcom...

Basrull N. Bhaludin, Khin Thway, Margaret Adejolu, Alexandra Renn… in Insights into Imaging (2021)

Article

NUT Carcinoma Arising from the Parotid Gland: A Case Report and Review of the Literature

NUT carcinoma is an aggressive carcinoma with an overall poor survival outcome. The mediastinum and head and neck area, especially the sinonasal region, are among the common sites of disease. Histopathological...

Wei-Ning Saik, Philip Da Forno, Khin Thway, Syed Ali Khurram in Head and Neck Pathology (2021)

Article

Predictive and prognostic transcriptomic biomarkers in soft tissue sarcomas

Soft tissue sarcomas (STS) are rare and heterogeneous tumours comprising over 80 different histological subtypes. Treatment options remain limited in advanced STS with high rates of recurrence following resect...

Eve Merry, Khin Thway, Robin L. Jones, Paul H. Huang in npj Precision Oncology (2021)

Article

Paraneoplastic dermatomyositis associated with metastatic leiomyosarcoma of unknown primary

Sarcomas are rare and heterogeneous tumours of mesenchymal origin, with over 100 histological subtypes. Paraneoplastic dermatomyositis has rarely been described in sarcoma. This is the first documented case of...

Eve Merry, Alannah Smrke, Kapil Halai, Gulam Patel, Khin Thway… in Clinical Sarcoma Research (2020)

Article

Soft Tissue Special Issue: Perivascular and Vascular Tumors of the Head and Neck

Perivascular and vascular neoplasms of the head and neck are a rare group of tumors comprising a spectrum of clinical/biologic and histological features. They are frequently diagnostically challenging, due to ...

Uta Flucke, Marie Karanian, Roel W. ten Broek, Khin Thway in Head and Neck Pathology (2020)

Article

Toxicity management of regorafenib in patients with gastro-intestinal stromal tumour (GIST) in a tertiary cancer centre

Regorafenib is a multi-kinase inhibitor approved as third line treatment for metastatic GIST. Dose limiting toxicities are frequently seen and many patients require dose reductions. This study aimed to evaluat...

Florence Chamberlain, Sheima Farag, Constance Williams-Sharkey… in Clinical Sarcoma Research (2020)

Article

Contemporary approaches to soft tissue and bone pathology

Khin Thway, Andrew L. Folpe in Virchows Archiv (2020)

Article

Adult soft tissue myoepithelial carcinoma: treatment outcomes and efficacy of chemotherapy

Soft tissue myoepithelial carcinomas are a rare, malignant subgroup of myoepithelial tumours mostly arising in the extremities with equal predilection for women and men. The mainstay of management of localised...

Florence Chamberlain, Elena Cojocaru, Mariana Scaranti… in Medical Oncology (2019)

Article

Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma

Cancer patients with advanced disease routinely exhaust available clinical regimens and lack actionable genomic medicine results, leaving a large patient population without effective treatments options when th...

Noah E. Berlow, Rishi Rikhi, Mathew Geltzeiler, **u Abraham… in BMC Cancer (2019)

Article

Clinical Characteristics and efficacy of chemotherapy in sclerosing epithelioid fibrosarcoma

Sclerosing epithelioid fibrosarcoma (SEF) is a very rare soft tissue sarcoma subtype. Clinically it is an aggressive tumour; however, to our knowledge there are no published reports regarding the efficacy of c...

Winston Chew, Charlotte Benson, Khin Thway, Andrew Hayes, Aisha Miah… in Medical Oncology (2018)

Article

Poor treatment outcomes with palliative gemcitabine and docetaxel chemotherapy in advanced and metastatic synovial sarcoma

The outcome for patients with unresectable or metastatic soft tissue sarcoma remains poor with few treatment options. Synovial sarcoma is a rare type of sarcoma, predominantly affecting adolescents and young a...

Alexandra Pender, Elizabeth J. Davis, Dharmisha Chauhan… in Medical Oncology (2018)

Article

The spectrum of EWSR1-rearranged neoplasms at a tertiary sarcoma centre; assessing 772 tumour specimens and the value of current ancillary molecular diagnostic modalities

EWSR1 rearrangements were first identified in Ewing sarcoma, but the spectrum of EWSR1-rearranged neoplasms now includes many soft tissue tumour subtypes including desmoplastic small round cell tumour (DSRCT), my...

Jonathan Noujaim, Robin L Jones, John Swansbury… in British Journal of Cancer (2017)

Article

Endosialin expression in soft tissue sarcoma as a potential marker of undifferentiated mesenchymal cells

Soft tissue sarcomas are a group of neoplasms with differentiation towards mesenchymal tissue, many of which are aggressive and chemotherapy resistant. Histology and immunoprofiles often overlap with neoplasms...

Khin Thway, David Robertson, Robin L Jones, Joanna Selfe… in British Journal of Cancer (2016)