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Article
Open AccessStudying genetic determinants of natural variation in human gene expression using Bayesian ANOVA
Standard genetic map** techniques scan chromosomal segments for location of genetic linkage and association signals. The majority of these methods consider only correlations at single markers and/or phenotyp...
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Article
Linkage and association analysis of candidate genes for TB and TNFα cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes
Tuberculosis (TB) is a growing public health threat globally and several studies suggest a role of host genetic susceptibility in increased TB risk. As part of a household contact study in Kampala, Uganda, we ...
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Article
Speech Sound Disorder Influenced by a Locus in 15q14 Region
Despite a growing body of evidence indicating that speech sound disorder (SSD) has an underlying genetic etiology, researchers have not yet identified specific genes predisposing to this condition. The speech ...
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Article
Open AccessAn artificial neural network for estimating haplotype frequencies
The problem of estimating haplotype frequencies from population data has been considered by numerous investigators, resulting in a wide variety of possible algorithmic and statistical solutions. We propose a r...
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Article
Open AccessA regression based transmission/disequilibrium test for binary traits: the power of joint tests for linkage and association
In this analysis we applied a regression based transmission disequilibrium test to the binary trait presence or absence of Kofendred Personality Disorder in the Genetic Analysis Workshop 14 (GAW14) simulated d...
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Article
Open AccessGenome-wide linkage scan for genes affecting longitudinal trends in systolic blood pressure
Only one genome scan to date has attempted to make use of the longitudinal data available in the Framingham Heart Study, and this attempt yielded evidence of linkage to a gene for mean systolic blood pressure....
