14 Result(s)
within
Courtney Gray-McGuire
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Chapter
Genetic Epidemiology of Obesity and Cancer
To understand the genetic epidemiology of obesity and cancer means to consider the genetics of not only these two complex diseases but also the many risk factors associated with them and the molecular mechanis...
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Article
Open AccessDefining genetic determinants of the Metabolic Syndrome in the Framingham Heart Study using association and structural equation modeling methods
The Metabolic Syndrome (MetSyn), which is a clustering of traits including insulin resistance, obesity, hypertension and dyslipidemia, is estimated to have a substantial genetic component, yet few specific gen...
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Article
Open AccessComparison of univariate and multivariate linkage analysis of traits related to hypertension
Complex traits are often manifested by multiple correlated traits. One example of this is hypertension (HTN), which is measured on a continuous scale by systolic blood pressure (SBP). Predisposition to HTN is ...
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Article
Open AccessMendelian randomization in family data
The phrase "mendelian randomization" has become associated with the use of genetic polymorphisms to uncover causal relationships between phenotypic variables. The statistical methods useful in mendelian random...
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Genetic association tests: a method for the joint analysis of family and case-control data
With the trend in molecular epidemiology towards both genome-wide association studies and complex modelling, the need for large sample sizes to detect small effects and to allow for the estimation of many para...
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Article
Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by both population and phenotypic heterogeneity. Our group previously identified linkage to SLE at 4p16 in European Americans (...
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Article
Genetic characterization and fine map** of susceptibility loci for sarcoidosis in African Americans on chromosome 5
Sarcoidosis, a systemic granulomatous disease, likely results from both environmental agents and genetic susceptibility. Sarcoidosis is more prevalent in women and, in the United States, African Americans are ...
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Article
Open AccessA regression based transmission/disequilibrium test for binary traits: the power of joint tests for linkage and association
In this analysis we applied a regression based transmission disequilibrium test to the binary trait presence or absence of Kofendred Personality Disorder in the Genetic Analysis Workshop 14 (GAW14) simulated d...
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Open AccessEffect of genoty** error in model-free linkage analysis using microsatellite or single-nucleotide polymorphism marker maps
Errors while genoty** are inevitable and can reduce the power to detect linkage. However, does genoty** error have the same impact on linkage results for single-nucleotide polymorphism (SNP) and microsatel...
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Open AccessGenetic Analysis Workshop 14: microsatellite and single-nucleotide polymorphism marker loci for genome-wide scans
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Article
Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder involving genetic and environmental factors. Previously, our group showed that SLE females with affected male relatives have higher prevalenc...
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Article
A review of the 'Statistical Analysis for Genetic Epidemiology' (SAGE) software package
The 'Statistical Analysis for Genetic Epidemiology' (S.A.G.E.) software package is an integrated, comprehensive package of computer programs designed to perform many of the different analyses required in the s...
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Open AccessGenome-wide linkage scan for genes affecting longitudinal trends in systolic blood pressure
Only one genome scan to date has attempted to make use of the longitudinal data available in the Framingham Heart Study, and this attempt yielded evidence of linkage to a gene for mean systolic blood pressure....
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Article
SLEB3 in systemic lupus erythematosus (SLE) is strongly related to SLE families ascertained through neuropsychiatric manifestations
Seizures and psychosis are neuropsychiatric (NP) manifestations of a large number of systemic lupus erythematosus (SLE) patients. Since NP manifestations were part of the SLE phenotype for some, but not all S...
