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Article
Influence of the irrigation flow pattern and catheter tip design on the lesion formation: an ex vivo experimental model
Lesion formation during catheter ablation is influenced by the power, contact force (CF), time, and catheter stability. However, the influence of the irrigation effects on lesion formation remains unknown.
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Article
Does the same lesion index mean the same efficacy and safety profile: influence of the differential power, time, and contact force on the lesion size and steam pops under the same lesion index
The lesion index (LSI) helps predict the lesion size and is widely used in ablation of various types of arrhythmias. However, the influence of the ablation settings on the lesion formation and incidence of ste...
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Article
Open AccessAge-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans
Average beat interval (BI) and beat interval variability (BIV) are primarily determined by mutual entrainment between the autonomic-nervous system (ANS) and intrinsic mechanisms that govern sinoatrial node (SA...
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Article
cAMP signaling affects age-associated deterioration of pacemaker beating interval dynamics
Sinoatrial node (SAN) beating interval variability (BIV) and the average beating interval (BI) are regulated by a coupled-clock system, driven by Ca2+-calmodulin activated adenylyl cyclase, cAMP, and downstream P...
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Article
Open AccessGeneralizable and robust deep learning algorithm for atrial fibrillation diagnosis across geography, ages and sexes
To drive health innovation that meets the needs of all and democratize healthcare, there is a need to assess the generalization performance of deep learning (DL) algorithms across various distribution shifts t...
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Article
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices
The prevalence of atria-related diseases increases exponentially with age and is associated with ATP supply-to-demand imbalances. Because evidence suggests that cAMP regulates ATP supply-to-demand, we explored...
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Article
Open AccessImpact of long-term optimizing atrioventricular delay using device-based algorithms on cardiac resynchronization therapy
Sub-optimal atrioventricular delay (AVD) is one of the main causes of non-responder for cardiac resynchronization therapy (CRT). Recently, device-based algorithms (DBAs) that provide optimal AVD based on intra...
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Article
The target ablation index values for electrical isolation of the superior vena cava
The ablation index (AI), developed as a radiofrequency (RF) catheter ablation composite component endpoint, which incorporates contact force (CF), time, and power in a weighted formula, has been reported to be...
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Article
Impact of high-density map** on outcome of the second ablation for atrial fibrillation
Identification of a conduction gap between the left atrium and pulmonary vein (LA-PV gap) and the circuit of atrial tachycardia after pulmonary vein isolation (PVI) is an important process during the second ab...
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Article
Methyl viologen induces neural differentiation on murine P19 cells
Methyl viologen is a highly effective contact herbicide, a neurotoxic compound and an inducer of reactive oxygen species, which generate oxidative stress in cells. Reactive oxygen species has been known to fun...
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Article
Open AccessA novel fluorescent protein from the deep-sea anemone Cribrinopsis japonica (Anthozoa: Actiniaria)
A fluorescent protein was identified and cloned from the deep-sea anemone Cribrinopsis japonica. Bioluminescence and fluorescence expression were examined by direct observations of live specimens and RNA-Seq anal...
