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Article
Central roles of iron in the regulation of oxidative stress in the yeast Saccharomyces cerevisiae
Oxygen is essential for aerobic organisms but causes cytotoxicity probably through the generation of reactive oxygen species (ROS). In this study, we screened for the genes that regulate oxidative stress in th...
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Article
Triphala, a formulation of traditional Ayurvedic medicine, shows protective effect against X-radiation in HeLa cells
Ayurveda is a holistic medical system of traditional medicine, and Triphala is one of the most popular formulations in Ayurveda. Triphala is composed of three kinds of herb, Terminalia chebula, Terminalia belliri...
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Article
Open AccessRestriction of protein synthesis abolishes senescence features at cellular and organismal levels
Cellular senescence or its equivalence is induced by treatment of cells with an appropriate inducer of senescence in various cell types. Mild restriction of cytoplasmic protein synthesis prevented induction of...
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Article
High concentrations of NaCl induce cell swelling leading to senescence in human cells
Cell swelling and retardation in DNA replication are always observed in senescent cells. When DNA replication is slowed down with RNA and protein syntheses unchanged in proliferating cells, it causes a phenom...
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Article
Identification of genes that affect sensitivity to 5-bromodeoxyuridine in the yeast Saccharomyces cerevisiae
Small molecules that exhibit biological effects have been successfully used to study various biological phenomena. 5-Bromodeoxyuridine (BrdU) is a thymidine analog that affects various biological processes, su...
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Article
Downregulation of hnRNP C1/C2 by siRNA sensitizes HeLa cells to various stresses
The heterogeneous nuclear ribonucleoprotein C1/C2 is one of the most abundant proteins in the nucleus, and shown to have roles in cellular differentiation and proliferation through post-transcriptional regulat...
