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Article
Persistence of the carteolol hydrochloride/latanoprost fixed-combination ophthalmic solution, compared with the other β-blocker/prostanoid FP receptor agonist fixed-combination ophthalmic solutions
To investigate the treatment persistence of carteolol hydrochloride/latanoprost fixed-combination ophthalmic solution (CAR/LAT) and other β-blocker/prostanoid FP receptor agonist fixed-combination ophthalmic s...
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Article
Comparison of one-year outcomes between as-needed brolucizumab and aflibercept for polypoidal choroidal vasculopathy
To compare the one-year visual and anatomic outcomes of an as-needed regimen of brolucizumab and aflibercept for polypoidal choroidal vasculopathy (PCV).
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Article
Open AccessGenetic variants associated with glaucomatous visual field loss in primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is characterized by a progressive optic neuropathy with visual field loss. To investigate the genetic variants associated with visual field loss in POAG, Japanese POAG patien...
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Article
Open AccessCharacteristics of intermediate age-related macular degeneration with hyperreflective foci
Hyperreflective foci (HRF) are the findings observed in optical coherence tomography (OCT) in several retinal diseases and are believed to be associated with the increased risk of atrophy in eyes with age-rela...
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Article
Japan Ocular Imaging Registry: a national ophthalmology real-world database
In 2017, the Japanese Ophthalmological Society (JOS) created the Japan Ocular Imaging (JOI) registry, a national database of images and clinical data in the field of ophthalmology in Japan. The JOI registry au...
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Article
Open AccessDistinct characteristics of central serous chorioretinopathy according to gender
To investigate the differences in clinical and genetic characteristics between males and females with central serous chorioretinopathy (CSC). Consecutive 302 patients (mean age; 56.3 ± 11.7, male/female: 249/5...
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Article
LineM: assessing metamorphopsia symptom using line manipulation task
Metamorphopsia patients experience distortions in their views. The number of metamorphopsia patients is arising with the increase in the elderly population. For early detection of metamorphopsia, examination a...
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Article
Enhancing edge indicator for visual field loss compensation for homonymous hemianopia patients
Homonymous hemianopia (HH) is a visual field defect in which the same side of both eyes is blind. In this paper, we propose an out-of-visual-field information compensation system for HH patients using an optic...
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Article
Open AccessIncidence and risk of advanced age-related macular degeneration in eyes with drusenoid pigment epithelial detachment
To investigate the incidence and risk of advanced age-related macular degeneration (AMD), including geographic atrophy (GA) and macular neovascularization (MNV), in eyes with drusenoid pigment epithelial detac...
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Article
Open AccessStalagmite evidence for East Asian winter monsoon variability and 18O-depleted surface water in the Japan Sea during the last glacial period
In the East Asian monsoon area, stalagmites generally record lower and higher oxygen isotope (δ18O) levels during warm humid interglacial and cold dry glacial periods, respectively. Here, we report unusually low ...
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Article
Open AccessEffect and underlying mechanisms of airborne particulate matter 2.5 (PM2.5) on cultured human corneal epithelial cells
Health problems caused by airborne particulate matter with a diameter less than 2.5 (PM2.5), especially in the respiratory system, have become a worldwide problem, but the influence and mechanisms of PM2.5 on ...
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Article
Association of CRP levels with ARMS2 and CFH variants in age-related macular degeneration
To investigate whether plasma high sensitivity C-reactive protein (hs-CRP) level is associated with exudative age-related macular degeneration (AMD) as well as variants of ARMS2 A69S and CFH I62V in patients with...
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Article
Open AccessSystemic and ocular diseases associated with the development of diabetic macular edema among Japanese patients with diabetes mellitus
Diabetic macular edema (DME) causes severe vision loss among patients with diabetes mellitus (DM). We aimed to investigate systemic and ocular diseases associated with the development of DME in a Japanese popu...
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Article
Open AccessPersistence and treatment patterns of fixed combination drugs for glaucoma: a retrospective claims database study in Japan
Poor persistence with glaucoma therapy can lead to disease progression and subsequent blindness. Persistence with second-line glaucoma combination treatment in a Japanese real-world setting and whether it diff...
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Article
Open AccessThe usefulness of the Deep Learning method of variational autoencoder to reduce measurement noise in glaucomatous visual fields
The aim of the study was to investigate the usefulness of processing visual field (VF) using a variational autoencoder (VAE). The training data consisted of 82,433 VFs from 16,836 eyes. Testing dataset 1 consi...
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Article
Open AccessGenetic factors associated with response to as-needed aflibercept therapy for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
In the present study, we investigated the association between susceptible genetic variants to age-related macular degeneration (AMD) and response to as-needed intravitreal aflibercept injection (IAI) therapy f...
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Article
Open AccessProcessing images for red–green dichromats compensation via naturalness and information-preservation considered recoloring
Color vision deficiency (CVD) is caused by anomalies in the cone cells of the human retina. It affects approximately 200 million individuals throughout the world. Although previous studies have proposed compen...
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Article
Evaluation of deep convolutional neural networks for glaucoma detection
To investigate the performance of deep convolutional neural networks (DCNNs) for glaucoma discrimination using color fundus images
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Article
A nationwide survey of factors influencing adherence to ocular hypotensive eyedrops in Japan
Few reports have investigated the status of adherence in Japan on a large scale. We aimed to investigate the status of adherence to topical glaucoma treatment and its associated factors.
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Article
Open AccessA Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice
Src knockout mice show no detectable abnormalities in central nervous system (CNS) post-mitotic neurons, likely reflecting functional compensation by other Src family kinases. Cdk1- or Cdk5-dependent Ser75 pho...
