4 Result(s)
within
Kelsie L Thu
Human Genetics
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Article
Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer
Mathieu Lupien and colleagues report an enrichment of somatic mutations at the ESR1 cis-regulatory region in 7% of ESR1-positive breast cancers. They find that the activity of the recurrently mutated ESR1 enhance...
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Article
Open AccessIdentification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer
While localized prostate cancer (PCa) can be effectively cured, metastatic disease inevitably progresses to a lethal state called castration-resistant prostate cancer (CRPC). Emerging evidence suggests that ab...
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Article
Open AccessPolycomb-mediated silencing in neuroendocrine prostate cancer
Neuroendocrine prostate cancer (NEPC) is a highly aggressive subtype of prostate cancer (PCa) for which the median survival remains less than a year. Current treatments are only palliative in nature, and the l...
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Protocol
Copy Number Variations in the Human Genome and Strategies for Analysis
The structure and sequence of the genome is immensely variable in the human population. Segmental copy number variants (CNVs) contribute to the extensive phenotypic diversity among humans and have been shown t...
