8 Result(s)
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Article
Role of the cGAS–STING pathway in systemic and organ-specific diseases
Cells are equipped with numerous sensors that recognize nucleic acids, which probably evolved for defence against viruses. Once triggered, these sensors stimulate the production of type I interferons and other...
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Article
The (Orf)ull truth about IRF5 and type I interferons in SLE
Exactly how nucleic acids trigger type I interferon responses via certain Toll-like receptors has been uncertain. Now, a new pathway involving gene products previously linked to systemic lupus erythematosus bu...
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Article
Aspirin meets cGAS
Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (...
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Article
Open AccessInnate and adaptive immune responses to dead and dying cells
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Article
Cytokines as therapeutic targets in SLE
A number of cytokine pathways are important in the disease process of SLE, and several biological agents for SLE have been developed that target different cytokines or their receptors. This Review discusses th...
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Article
Open AccessB-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin
B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL) are members of the tumor necrosis factor (TNF) family that regulate B-cell maturation, survival, and function. They are overexpressed ...
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Article
Shining light on lupus and UV
People exposed to sunlight can develop erythema, DNA damage, and photoimmunosupression. Extended exposure of normal epidermis to sunlight will induce dysmorphic keratinocytes with pyknotic nuclei scattered thr...
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Chapter
Ribosomal RNP
