Skip to main content

6 Result(s)

within Keith B. Elkon Remove this filter Biomedicine Remove this filter

and

  1. No Access

    Article

    Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

    Lupus-like disease is driven by NETs enriched in mitochondrial DNA.

    Christian Lood, Luz P Blanco, Monica M Purmalek, Carmelo Carmona-Rivera… in Nature Medicine (2016)

  2. No Access

    Chapter

    Naturally Occurring Autoantibodies to Apoptotic Cells

    Subsets of IgM naturally occurring autoantibodies (NAbs) bind to the cell surface membranes of dying cells. The antibodies predominantly have specificities against lipid antigens or oxidized lipids. Chief amon...

    Keith B. Elkon, Gregg J. Silverman in Naturally Occurring Antibodies (NAbs) (2012)

  3. No Access

    Article

    Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature

    Yanick Crow and colleagues show that mutations in ACP5, which encodes tartrate-resistant acid phosphatase, cause spondyloenchondrodysplasia, a bone dysplasia with autoimmunity. The affected individuals had elevat...

    Tracy A Briggs, Gillian I Rice, Sarah Daly, Jill Urquhart… in Nature Genetics (2011)

  4. No Access

    Article

    Autoimmunity: apoptotic fats grease transcription

    Transcription factors known for handling the body's response to lipids promote clearance of apoptotic cells by macrophages, according to new research (pages 1266–1272

    Keith B Elkon in Nature Medicine (2009)

  5. No Access

    Article

    IL-1α responds to necrotic cell death

    Necrosis induces inflammation, but how necrotic cells signal to immune cells was poorly understood. New work by Chen et al. shows that IL-1α acts as a mediator, translating a signal from the necrotic cells to ind...

    Keith B Elkon in Nature Medicine (2007)

  6. No Access

    Chapter

    Antiribosomal Antibodies in SLE, Infection, and Following Deliberate Immunization

    It has long been known that patients with systemic lupus erythematosus (SLE) and related diseases have, in addition to antinuclear antibodies (ANA), autoantibodies directed against cytoplasmic constituents1,2. In...

    Keith B. Elkon, Eloisa Bonfa… in Immunobiology of Proteins and Peptides VII (1994)