14 Result(s)
within
Keisuke Ito
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessResilient anatomy and local plasticity of naive and stress haematopoiesis
The bone marrow adjusts blood cell production to meet physiological demands in response to insults. The spatial organization of normal and stress responses are unknown owing to the lack of methods to visualize...
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Article
Open AccessAnti-nanodisc antibodies specifically capture nanodiscs and facilitate molecular interaction kinetics studies for membrane protein
Nanodisc technology has dramatically advanced the analysis of molecular interactions for membrane proteins. A nanodisc is designed as a vehicle for membrane proteins that provide a native-like phospholipid env...
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Article
Open AccessA conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity
Land plants produce diverse flavonoids for growth, survival, and reproduction. Chalcone synthase is the first committed enzyme of the flavonoid biosynthetic pathway and catalyzes the production of 2′,4,4′,6′-t...
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Article
Open AccessIdentification of soybean peptide leginsulin variants in different cultivars and their insulin-like activities
We have recently reported that green soybean cultivar, echigomidori, and not the yellow cultivar, fukuyutaka, is a rich source of hormone-like peptide leginsulin consisting of 37 amino acids (Leg_1_37, PDB 1JU8A)...
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Article
Open AccessA non-cell-autonomous role for Pml in the maintenance of leukemia from the niche
Disease recurrence after therapy, due to the persistence of resistant leukemic cells, represents a fundamental problem in the treatment of leukemia. Elucidating the mechanisms responsible for the maintenance o...
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Article
Open AccessImage-guided transplantation of single cells in the bone marrow of live animals
Transplantation of a single hematopoietic stem cell is an important method for its functional characterization, but the standard transplantation protocol relies on cell homing to the bone marrow after intraven...
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Article
DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier
Histone methyl-transferase MLL4 is required for stem-cell activity and an aggressive form of acute myeloid leukaemia harbouring the MLL–AF9 oncogene.
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Article
Arteriolar niches maintain haematopoietic stem cell quiescence
Cell cycle quiescence is a critical feature contributing to haematopoietic stem cell (HSC) maintenance. Although various candidate stromal cells have been identified as potential HSC niches, the spatial locali...
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Article
Open AccessAnalysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library
Peptide uptake systems that involve members of the proton-coupled oligopeptide transporter (POT) family are conserved across all organisms. POT proteins have characteristic substrate multispecificity, with whi...
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Article
PML targeting eradicates quiescent leukaemia-initiating cells
The existence of a small population of ‘cancer-initiating cells’ responsible for tumour maintenance has been firmly demonstrated in leukaemia. This concept is currently being tested in solid tumours. Leukaemia...
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Article
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
The ‘ataxia telangiectasia mutated’ (Atm) gene maintains genomic stability by activating a key cell-cycle checkpoint in response to DNA damage, telomeric instability or oxidative stress1,2. Mutational inactivatio...
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Chapter
Towards a New View of Earthquake Phenomena
Recent advances in the theory of fracture and fragmentation are reviewed. Empirical laws in seismology are interpreted from a fractal perspective, and earthquakes are viewed as a self-organized critical phenom...
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Chapter
Multifractal Analysis of Earthquakes
Multifractal properties of the epicenter and hypocenter distribution and also of the energy distribution of earthquakes are studied for California, Japan, and Greece. The calculated D ...
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Article
Noble-gas enrichment in vapour-growth diamonds and the origin of diamonds in ureilites
Ureilites show high carbon contents comparable with those of CM chondrites1,2. One of the major questions about ureilites is why they contain large amounts of noble gases concentrated in carbon-rich veins3,4. Dia...
