Skip to main content

7 Result(s)

within Keisuke Ito Remove this filter Cancer Research Remove this filter

and

  1. No Access

    Article

    Primary spinal intramedullary Ewing-like sarcoma harboring CIC-DUX4 translocation: a similar cytological appearance as its soft tissue counterpart but no lobulation in association with desmoplastic stroma

    The CIC-DUX4 translocation is the most common genetic alteration of small round cell sarcomas without EWSR1 rearrangement. These “Ewing-like sarcomas” usually occur in peripheral soft tissues, and rare primary ce...

    Seiji Yamada, Jun Muto, John Clemente Aniceto De Leon… in Brain Tumor Pathology (2020)

  2. No Access

    Article

    Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita

    RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are lacking. Here, we link ribosomal RNA 2′-O-methylation (...

    Daphna Nachmani, Anne H. Bothmer, Silvia Grisendi, Aldo Mele… in Nature Genetics (2019)

  3. No Access

    Article

    Effect of Notch expression in glioma stem cells on therapeutic response to chemo-radiotherapy in recurrent glioblastoma

    Glioma stem cells (GSCs) have the capacity to repopulate tumors and mediate resistance to radiotherapy and chemotherapy. The Notch signaling pathway is important in proliferation, stem cell maintenance, cell d...

    Norihiko Saito, Kazuya Aoki, Nozomi Hirai, Satoshi Fujita… in Brain Tumor Pathology (2015)

  4. No Access

    Article

    Metabolic requirements for the maintenance of self-renewing stem cells

  5. Stem cells perpetuate themselves through self-renewal and they replenish mature cells to maintain tissue homeostasis throughout the lifespan of an organism.

    ...

    6. Keisuke Ito, Toshio Suda in Nature Reviews Molecular Cell Biology (2014)

  6. No Access

    Article

    A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

    Keisuke Ito et al. uncover a new pathway regulating hematopoietic stem cell maintenance and function. In this pathway, the promyelocytic leukemia protein (PML) regulates the activity of the PPAR-δ nuclear hormone...

    Keisuke Ito, Arkaitz Carracedo, Dror Weiss, Fumio Arai, Ugo Ala… in Nature Medicine (2012)

  7. Article

    Correction: Corrigendum: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

    Nat. Med. 12, 446–451 (2006); published online 26 March 2006; corrected after print 7 January 2010 In the version of this article initially published, two micrographs in Figure 2c, corresponding to the conditi...

    Keisuke Ito, Atsushi Hirao, Fumio Arai, Keiyo Takubo, Sahoko Matsuoka… in Nature Medicine (2010)

    Download PDF (90 KB) View Article

  8. No Access

    Article

    Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

    Hematopoietic stem cells (HSCs) undergo self-renewing cell divisions and maintain blood production for their lifetime1. Appropriate control of HSC self-renewal is crucial for the maintenance of hematopoietic home...

    Keisuke Ito, Atsushi Hirao, Fumio Arai, Keiyo Takubo, Sahoko Matsuoka… in Nature Medicine (2006)