Skip to main content

4 Result(s)

within Keisuke Ito Remove this filter Biomedicine Remove this filter Cancer Research Remove this filter

and

  1. No Access

    Article

    Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita

    RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are lacking. Here, we link ribosomal RNA 2′-O-methylation (...

    Daphna Nachmani, Anne H. Bothmer, Silvia Grisendi, Aldo Mele… in Nature Genetics (2019)

  2. No Access

    Article

    A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

    Keisuke Ito et al. uncover a new pathway regulating hematopoietic stem cell maintenance and function. In this pathway, the promyelocytic leukemia protein (PML) regulates the activity of the PPAR-δ nuclear hormone...

    Keisuke Ito, Arkaitz Carracedo, Dror Weiss, Fumio Arai, Ugo Ala… in Nature Medicine (2012)

  3. Article

    Correction: Corrigendum: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

    Nat. Med. 12, 446–451 (2006); published online 26 March 2006; corrected after print 7 January 2010 In the version of this article initially published, two micrographs in Figure 2c, corresponding to the conditi...

    Keisuke Ito, Atsushi Hirao, Fumio Arai, Keiyo Takubo, Sahoko Matsuoka… in Nature Medicine (2010)

    Download PDF (90 KB) View Article

  4. No Access

    Article

    Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

    Hematopoietic stem cells (HSCs) undergo self-renewing cell divisions and maintain blood production for their lifetime1. Appropriate control of HSC self-renewal is crucial for the maintenance of hematopoietic home...

    Keisuke Ito, Atsushi Hirao, Fumio Arai, Keiyo Takubo, Sahoko Matsuoka… in Nature Medicine (2006)