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Article
Germline NPM1 mutations lead to altered rRNA 2′-O-methylation and cause dyskeratosis congenita
RNA modifications are emerging as key determinants of gene expression. However, compelling genetic demonstrations of their relevance to human disease are lacking. Here, we link ribosomal RNA 2′-O-methylation (...
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Article
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
Keisuke Ito et al. uncover a new pathway regulating hematopoietic stem cell maintenance and function. In this pathway, the promyelocytic leukemia protein (PML) regulates the activity of the PPAR-δ nuclear hormone...
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Article
Correction: Corrigendum: Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Nat. Med. 12, 446–451 (2006); published online 26 March 2006; corrected after print 7 January 2010 In the version of this article initially published, two micrographs in Figure 2c, corresponding to the conditi...
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Article
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Hematopoietic stem cells (HSCs) undergo self-renewing cell divisions and maintain blood production for their lifetime1. Appropriate control of HSC self-renewal is crucial for the maintenance of hematopoietic home...