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Open AccessAssociations of plasma proteomics and age-related outcomes with brain age in a diverse cohort
Machine learning models are increasingly being used to estimate “brain age” from neuroimaging data. The gap between chronological age and the estimated brain age gap (BAG) is potentially a measure of accelerat...
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Article
Mid-life plasma proteins associated with late-life prefrailty and frailty: a proteomic analysis
Physical frailty is a syndrome that typically manifests in later life, although the pathogenic process causing physical frailty likely begins decades earlier. To date, few studies have examined the biological ...
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Article
Severe infections as a gateway to dementia
A study in Nature Aging on electronic health records from 1.7 million people in New Zealand reveals that most patients with dementia have a history of hospital-treated infection. In a dementia-free population, in...
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Open AccessProteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks
Despite the wide effects of cardiorespiratory fitness (CRF) on metabolic, cardiovascular, pulmonary and neurological health, challenges in the feasibility and reproducibility of CRF measurements have impeded i...
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Article
Open AccessAssociation between retinal microvascular abnormalities and late-life brain amyloid-β deposition: the ARIC-PET study
Retinal microvascular signs are accessible measures of early alterations in microvascular dysregulation and have been associated with dementia; it is unclear if they are associated with AD (Alzheimer’s disease...
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Open AccessAlzheimer’s and neurodegenerative disease biomarkers in blood predict brain atrophy and cognitive decline
Although blood-based biomarkers have been identified as cost-effective and scalable alternatives to PET and CSF markers of neurodegenerative disease, little is known about how these biomarkers predict future b...
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Article
Open AccessAssociations between genetically predicted plasma protein levels and Alzheimer’s disease risk: a study using genetic prediction models
Specific peripheral proteins have been implicated to play an important role in the development of Alzheimer’s disease (AD). However, the roles of additional novel protein biomarkers in AD etiology remains elus...
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Open AccessIdentification of circulating proteins associated with general cognitive function among middle-aged and older adults
Identifying circulating proteins associated with cognitive function may point to biomarkers and molecular process of cognitive impairment. Few studies have investigated the association between circulating prot...
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Article
Open AccessThe role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap
Peripheral inflammation, defined as inflammation that occurs outside the central nervous system, is an age-related phenomenon that has been identified as a risk factor for Alzheimer’s disease. While the role o...
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Open AccessCorrection to: Plasma proteins related to inflammatory diet predict future cognitive impairment
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Open AccessPlasma proteins related to inflammatory diet predict future cognitive impairment
Dysregulation of the immune system and dietary patterns that increase inflammation can increase the risk for cognitive decline, but the mechanisms by which inflammatory nutritional habits may affect the develo...
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Article
New IDEAS about amyloid, race and dementia disparities
In a study of 17,000 Medicare beneficiaries with mild cognitive impairment or dementia, non-Hispanic white older adults were more likely than Asian, Black or Hispanic older adults to have elevated cortical amy...
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Open AccessAssessment of variability in the plasma 7k SomaScan proteomics assay
SomaScan is a high-throughput, aptamer-based proteomics assay designed for the simultaneous measurement of thousands of proteins with a broad range of endogenous concentrations. In its most current version, th...
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Article
Reducing decoys focuses fighting microglia
Genetic variation linked to lower levels of soluble ST2, a decoy cytokine receptor for IL-33, may protect against Alzheimer’s disease in women carrying the APOEε4 allele by increasing microglial plaque removal. T...
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The Role of Chronic Infection in Alzheimer’s Disease: Instigators, Co-conspirators, or Bystanders?
Herein, we provide a critical review of the clinical and translational research examining the relationship between viral and bacterial pathogens and Alzheimer’s disease. In addition, we provide an overview of ...
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Large-scale plasma proteomic analysis identifies proteins and pathways associated with dementia risk
The plasma proteomic changes that precede the onset of dementia could yield insights into disease biology and highlight new biomarkers and avenues for intervention. We quantified 4,877 plasma proteins in nonde...
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Defining the Relationship Between Hypertension, Cognitive Decline, and Dementia: a Review
Hypertension is a highly prevalent condition which has been established as a risk factor for cardiovascular and cerebrovascular disease. Although the understanding of the relationship between cardiocirculatory...
