Genetic variation linked to lower levels of soluble ST2, a decoy cytokine receptor for IL-33, may protect against Alzheimer’s disease in women carrying the APOEε4 allele by increasing microglial plaque removal. This discovery advances our understanding of the immune system’s role in Alzheimer’s disease and underscores the importance of sex-specific disease processes.
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The authors are supported by the Intramural Research Program of the NIH, National Institute on Aging.
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Duggan, M.R., Walker, K.A. Reducing decoys focuses fighting microglia. Nat Aging 2, 573–575 (2022). https://doi.org/10.1038/s43587-022-00251-7
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DOI: https://doi.org/10.1038/s43587-022-00251-7
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