-
Article
Open AccessUnleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors
New therapies are urgently needed in melanoma, particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors. To uncover novel potentiators of T cell anti-tumor immunity, we carri...
-
Article
Open AccessProgranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
Immune evasion is indispensable for cancer initiation and progression, although its underlying mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not fully known. Here, we characterize the function of t...
-
Article
Open AccessSlow viral propagation during initial phase of infection leads to viral persistence in mice
Immune evasion of pathogens can modify the course of infection and impact viral persistence and pathology. Here, using different strains of the lymphocytic choriomeningitis virus (LCMV) model system, we show t...
-
Article
Publisher Correction: Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Glucose transport in lymphocytes
Glucose uptake into lymphocytes is accomplished by non-concentrative glucose carriers of the GLUT family (GLUT1, GLUT3, GLUT4, GLUT6) and/or by the Na+-coupled glucose carrier SGLT1. The latter accumulates glucos...
-
Article
Open AccessAcid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
Macrophages have important protective functions during infection with herpes simplex virus type 1 (HSV-1). However, molecular mechanisms that restrict viral propagation and protect from severe disease are uncl...
-
Article
Open AccessRepurposing the serotonin agonist Tegaserod as an anticancer agent in melanoma: molecular mechanisms and clinical implications
New therapies are urgently needed in melanoma particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors.
-
Article
Open AccessCholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection
Immune responses are critical for defense against pathogens. However, prolonged viral infection can result in defective T cell immunity, leading to chronic viral infection. We studied immune activation in resp...
-
Article
Open AccessCEACAM1 promotes CD8+ T cell responses and improves control of a chronic viral infection
Dysfunction of CD8+ T cells can lead to the development of chronic viral infection. Identifying mechanisms responsible for such T cell dysfunction is therefore of great importance to understand how to prevent per...
-
Article
Open AccessTNFα induced up-regulation of Na+,K+,2Cl− cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity
The devastating consequences of hepatic failure include hepatic encephalopathy, a severe, life threatening impairment of neuronal function. Hepatic encephalopathy is caused by impaired hepatic clearance of NH4 ...
-
Article
Open AccessSpatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression
Immune-mediated effector molecules can limit cancer growth, but lack of sustained immune activation in the tumour microenvironment restricts antitumour immunity. New therapeutic approaches that induce a strong...
-
Article
Multiple functions of USP18
Since the discovery of the ubiquitin system and the description of its important role in the degradation of proteins, many studies have shown the importance of ubiquitin-specific peptidases (USPs). One special...
-
Article
Open AccessCD169+ macrophages regulate PD-L1 expression via type I interferon and thereby prevent severe immunopathology after LCMV infection
Upon infection with persistence-prone virus, type I interferon (IFN-I) mediates antiviral activity and also upregulates the expression of programmed death ligand 1 (PD-L1), and this upregulation can lead to CD8+ ...
-
Article
Open AccessInduction of the type I interferon response in neurological forms of Gaucher disease
Neuroinflammation is a key phenomenon in the pathogenesis of many neurodegenerative diseases. Understanding the mechanisms by which brain inflammation is engaged and delineating the key players in the immune r...
-
Article
Tumor-necrosis factor impairs CD4+ T cell–mediated immunological control in chronic viral infection
Functional T cell exhaustion occurs during chronic viral infection or in tumor settings. Beyer et al. report that chronic inflammation mediated by the cytokine TNF is responsible for this dysfunction and that blo...
-
Article
Open AccessVirus-specific antibodies allow viral replication in the marginal zone, thereby promoting CD8+ T-cell priming and viral control
Clinically used human vaccination aims to induce specific antibodies that can guarantee long-term protection against a pathogen. The reasons that other immune components often fail to induce protective immunit...
-
Article
Open AccessTLR ligand induced IL-6 counter-regulates the anti-viral CD8+ T cell response during an acute retrovirus infection
We have previously shown that Toll-like receptor (TLR) agonists contribute to the control of viral infection by augmenting virus-specific CD8+ T-cell responses. It is also well established that signaling by TLRs ...
-
Article
Open AccessCEACAM1 induces B-cell survival and is essential for protective antiviral antibody production
B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is ess...
-
Article
Open AccessImmune functions during chronic viral infections
-
Article
Open AccessEnforced viral replication, a mechanism for immune activation
