-
Article
Common Pathways in Depression and Obesity: The Role of Gut Microbiome and Diets
This paper aims to review data regarding two determinants of comorbidity between depression and obesity, i.e., the role of disturbed gut microbiome in their genesis and of diets in their treatment.
-
Article
Open AccessGallic acid, a common dietary phenolic protects against high fat diet induced DNA damage
Aim of the study was to find out if gallic acid (GA), a common phenolic in plant foods, prevents obesity induced DNA damage which plays a key role in the induction of overweight associated cancer.
-
Article
Genetic deficiency of the tumor suppressor protein p53 influences erythrocyte survival
The transcription factor p53 suppresses tumor growth by inducing nucleated cell apoptosis and cycle arrest. Because of its influence on primitive erythroid cell differentiation and survival, p53 is an importan...
-
Article
Open AccessCholestasis induced liver pathology results in dysfunctional immune responses after arenavirus infection
Immune responses are critical for defense against pathogens. However, prolonged viral infection can result in defective T cell immunity, leading to chronic viral infection. We studied immune activation in resp...
-
Article
Open AccessTNFα induced up-regulation of Na+,K+,2Cl− cotransporter NKCC1 in hepatic ammonia clearance and cerebral ammonia toxicity
The devastating consequences of hepatic failure include hepatic encephalopathy, a severe, life threatening impairment of neuronal function. Hepatic encephalopathy is caused by impaired hepatic clearance of NH4 ...
-
Article
Open AccessThe employability of ex-offenders: a field experiment in the Swedish labor market
This paper presents the findings of a field experiment on hiring discrimination against ex-offenders in the Swedish labor market. Matched pairs of written job applications for fictitious male and female applic...
-
Article
Open AccessBlunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit Gαi2
Putative functions of the heterotrimeric G-protein subunit Gαi2-dependent signaling include ion channel regulation, cell differentiation, proliferation and apoptosis. Erythrocytes may, similar to apoptosis of ...
-
Article
Open AccessAccelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2
The mitogen- and stress-activated kinase MSK1/2 plays a decisive role in apoptosis. In analogy to apoptosis of nucleated cells, suicidal erythrocyte death called eryptosis is characterized by cell shrinkage an...
-
Article
Ceramide in the regulation of eryptosis, the suicidal erythrocyte death
Similar to apoptosis of nucleated cells, erythrocytes may undergo eryptosis, a suicidal death characterized by cell shrinkage and phospholipid scrambling of the cell membrane leading to phosphatidylserine expo...
-
Article
Open AccessCEACAM1 induces B-cell survival and is essential for protective antiviral antibody production
B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is ess...
-
Article
Enhanced eryptosis of erythrocytes from gene-targeted mice lacking annexin A7
Annexin A7 is a ubiquitously expressed Ca2+- and phospholipid-binding protein. Erythrocytes from mice lacking annexin A7 (anxA7 −/− ) are deformed and re...
-
Article
Adenosine protects against suicidal erythrocyte death
Suicidal death of erythrocytes or eryptosis is characterized by cell shrinkage and cell membrane scrambling leading to phosphatidylserine exposure at the erythrocyte surface. The cell membrane scrambling is tr...
