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Article
Mismatch in how oestrogen modulates molecular and neuronal function may explain menstrual migraine
This paper is designed to provide concepts and stimulate directions for further investigation of menstrual migraine. On the basis of experimental studies and literature review, we propose that abnormalities in...
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Article
Research developments in the physiopathology of primary headaches
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Article
Concepts of migraine headache pathogenesis: insights into mechanisms of chronicity and new drug targets
The pathophysiology of migraine is incompletely understood. Neurobiological and gene regulation studies and advanced brain imaging are providing new insights into migraine pathogenesis. Recent discoveries hav...
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Chapter
Are Heart Attacks Really Brain Attacks?
In 1664, Thomas Willis recognized that the brain and the cardiovascular system are interdependent-when he wrote De Anatome Cerebri (Willis 1664). For the relief of angina pain, Francois Franck, in 1899, proposed ...
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Chapter and Conference Paper
Photoactivation of Hematoporphyrin Derivative in Cat Brain: A Model of Ischemic Necrosis
Hematoporphyrin derivative (HpD) is under investigation as a phototherapeutic agent for the treatment of cerebral neoplasia (McCulloch et al, 1983). When illuminated with red light (wavelength 631 nm) in the p...
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Chapter and Conference Paper
Contribution of Platelet Aggregation and Serotonin Release to Progressive Cerebral Infarction
Prevention and amelioration of acute cerebral infarction resulting from occlusion of the aortocerebral arterial circulation is best effected by maintenance of tissue metabolic viability by enhancing the cerebr...
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Chapter and Conference Paper
The Role of Biogenic Amines in the Progression of Cerebral Ischemia and Edema: Modification by p-Chlorophenylalanine, Methysergide, and Pentoxyfilline
Disorders of monoamine neurotransmitter metabolism, particularly 5-hydroxytryptamine and dopamine, may play some part in the early development of edema and in the progression of ischemia. This early edema seem...