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  1. Article

    Effects of immunosuppression on alpha and beta cell renewal in transplanted mouse islets

    Immunosuppressive drugs used in human islet transplantation interfere with the balance between beta cell renewal and death, and thus may contribute to progressive graft dysfunction. We analysed the influence o...

    C. Krautz, S. Wolk, A. Steffen, K.-P. Knoch, U. Ceglarek, J. Thiery… in Diabetologia (2013)

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    Chapter and Conference Paper

    Betazellregeneration transplantierter Inseln im Mausmodell

    Background: Antiproliferative effects of immunosuppressants used in human islet transplantation interfere with the capability of the beta cells to balance cell renewal and cell loss. Cons...

    Dr. med. Christian Krautz, S. Wolk, A. Steffen… in Chirurgisches Forum und DGAV Forum 2010 (2010)

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    Chapter and Conference Paper

    Gentransfer in isolierten Langerhans-Inseln mit einem lentiviralen Vektorsystem

    Introduction: Transplantation of isolated human islets as cell-based therapy of type I diabetes mellitus became possible since several years. Its wide application, however, is limited by the lack...

    Ronny Meisterfeld, F. Ehehalt, K. -P. Knoch, E. Wündrich… in Chirurgisches Forum 2008 (2008)

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    Chapter and Conference Paper

    Erniedrigte Insulin-Biogenese in Langerhans-Inseln aus Pankreasteilresektaten von Typ 2-Diabetikern

    Failure of pancreatic β-cells contributes to the development of type 2 diabetes. Besides evidence of reduced glucose-stimulated insulin secretion and β-cell mass, little information is available about the mole...

    Dr. med. Florian Ehehalt, K. P. Knoch, R. Meisterfeld… in Chirurgisches Forum 2008 (2008)

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    Chapter and Conference Paper

    Die nukleär-cytosolische Translokation von PTB1 in Langerhans-Inseln — ein potentieller Marker für die Inselqualität vor der Transplantation

    High glucose concentrations trigger the translocation of polypyrimidine-tract-binding protein 1 (PTB1) from the nucleus to the cytosol, where it stabilizes the mRNA of insulin and secretory granule proteins, ther...

    Dr. med. Florian Ehehalt, K. P. Knoch, K. Erdmann, S. Kersting… in Chirurgisches Forum 2007 (2007)

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    Chapter and Conference Paper

    Entwicklung eines molekularen Assay zur Prüfung der Inselzellqualität vor Transplantation im diabetischen Tiermodell

    Introduction: Since the recent introduction of the Edmonton experience by Shapiro et al. the trans-plantation of insulin producing tissue has become an attractive therapeutic approach for the treatment of type 1 ...

    Dr. Hendrik Bergert, S. Kersting, R. Meisterfeld, H. D. Saeger… in Chirurgisches Forum 2005 (2005)

  7. Article

    40th EASD Annual Meeting of the European Association for the Study of Diabetes

    M. Veitenhansl, K. Stegner, F.-X. Hierl, C. Dieterle, H. Feldmeier, B. Gutt… in Diabetologia (2004)

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