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    Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma

    Myeloid-derived suppressor cells (MDSCs) accumulate in the glioma microenvironment during tumor progression and promote immunosuppression. Interleukin-12 (IL-12) immunogene therapy can alter MDSCs toward an an...

    B Thaci, A U Ahmed, I V Ulasov, D A Wainwright, P Nigam, B Auffinger… in Cancer Gene Therapy (2014)