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  1. No Access

    Article

    Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma

    Myeloid-derived suppressor cells (MDSCs) accumulate in the glioma microenvironment during tumor progression and promote immunosuppression. Interleukin-12 (IL-12) immunogene therapy can alter MDSCs toward an an...

    B Thaci, A U Ahmed, I V Ulasov, D A Wainwright, P Nigam, B Auffinger… in Cancer Gene Therapy (2014)

  2. No Access

    Article

    Anti-angiogenic therapy increases intratumoral adenovirus distribution by inducing collagen degradation

    Conditionally replicating adenoviruses (CRAd) are a promising class of gene therapy agents that can overcome already known glioblastoma (GBM) resistance mechanisms but have limited distribution upon direct int...

    B Thaci, I V Ulasov, A U Ahmed, S D Ferguson, Y Han, M S Lesniak in Gene Therapy (2013)

  3. Article

    Pharmacokinetic study of neural stem cell-based cell carrier for oncolytic virotherapy: targeted delivery of the therapeutic payload in an orthotopic brain tumor model

    Oncolytic virotherapy is a promising novel therapy for glioblastoma that needs to be optimized before introduced to clinic. The targeting of conditionally replicating adenoviruses (CRAds) can be improved by re...

    B Thaci, A U Ahmed, I V Ulasov, A L Tobias, Y Han, K S Aboody… in Cancer Gene Therapy (2012)

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  4. No Access

    Article

    Biodistribution of an oncolytic adenovirus after intracranial injection in permissive animals: a comparative study of Syrian hamsters and cotton rats

    Conditionally replicative adenoviruses (CRAds) are often evaluated in mice; however, normal and cancerous mouse tissues are poorly permissive for human CRAds. As the cotton rat (CR) is a semipermissive animal ...

    A M Sonabend, I V Ulasov, Y Han, C E Rolle, S Nandi, D Cao… in Cancer Gene Therapy (2009)

  5. Article

    Open Access

    Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo

    Conditionally replicative adenoviruses (CRAds) represent a novel treatment strategy for malignant glioma. Recent studies suggest that the cytopathic effect elicited by these vectors is mediated through autopha...

    I V Ulasov, A M Sonabend, S Nandi, A Khramtsov, Y Han… in British Journal of Cancer (2009)

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  6. No Access

    Article

    Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo

    Adenoviral oncolytic virotherapy represents an attractive treatment modality for central nervous system (CNS) neoplasms. However, successful application of virotherapy in clinical trials has been hampered by i...

    M A Tyler, I V Ulasov, A M Sonabend, S Nandi, Y Han, S Marler, J Roth… in Gene Therapy (2009)