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Article
Analysis of glioblastoma tumor coverage by oncolytic virus-loaded neural stem cells using MRI-based tracking and histological reconstruction
In preclinical studies, neural stem cell (NSC)-based delivery of oncolytic virus has shown great promise in the treatment of malignant glioma. Ensuring the success of this therapy will require critical evaluat...
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Article
Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy
Glioblastoma multiforme patients have a poor prognosis due to therapeutic resistance and tumor relapse. It has been suggested that gliomas are driven by a rare subset of tumor cells known as glioma stem cells ...
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Article
Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma
Myeloid-derived suppressor cells (MDSCs) accumulate in the glioma microenvironment during tumor progression and promote immunosuppression. Interleukin-12 (IL-12) immunogene therapy can alter MDSCs toward an an...
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Article
Anti-angiogenic therapy increases intratumoral adenovirus distribution by inducing collagen degradation
Conditionally replicating adenoviruses (CRAd) are a promising class of gene therapy agents that can overcome already known glioblastoma (GBM) resistance mechanisms but have limited distribution upon direct int...
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Article
Pharmacokinetic study of neural stem cell-based cell carrier for oncolytic virotherapy: targeted delivery of the therapeutic payload in an orthotopic brain tumor model
Oncolytic virotherapy is a promising novel therapy for glioblastoma that needs to be optimized before introduced to clinic. The targeting of conditionally replicating adenoviruses (CRAds) can be improved by re...
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Article
In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it
Binding of TNF to TNF receptor-1 can give a pro-survival signal through activation of p65/RelA NF-κB, but also signals cell death. To determine the roles of FLICE-inhibitory protein (FLIP) and caspase-8 in TNF-in...
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Chapter
Effect of Climatic Changes on the Incidence of Disease of Winter Pulses
The accelerated population growth of Bangladesh has triggered the need for increased food production. To meet the demand of food for increasing population Bangladesh has no other alternative to increase its cr...
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Article
Electrical Properties of Thermally Grown SiO2-SiC Interfaces
Fabrication processes of metal-oxide semiconductor (MOS) capacitors on n-type, Si-face, 6H-SiC were studied. The effects of thermal oxidation conditions at temperatures between 1100 and 1250°C on the electrica...
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Article
The growth and characterization of GaN on sapphire and silicon
MOCVD (metalorganic chemical vapor deposition) of GaN on both silicon and sapphire substrates was studied over the temperature range of 370 to 1050° C. The crystallinity and surface morphology of the films var...
