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  1. No Access

    Article

    Cartilage oligomeric matrix protein contributes to the development and metastasis of breast cancer

    Cartilage oligomeric matrix protein (COMP) is a soluble pentameric protein expressed in cartilage and involved in collagen organization. Tissue microarrays derived from two cohorts of patients with breast canc...

    E Englund, M Bartoschek, B Reitsma, L Jacobsson, A Escudero-Esparza, A Orimo… in Oncogene (2016)

  2. Article

    Open Access

    Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML

    Therapy directed against oncogenic FLT3 has been shown to induce response in patients with acute myeloid leukemia (AML), but these responses are almost always transient. To address the mechanism of FLT3 inhibi...

    O Lindblad, E Cordero, A Puissant, L Macaulay, A Ramos, N N Kabir, J Sun… in Oncogene (2016)

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    Article

    Molecular biology of neuroendocrine tumors: from pathways to biomarkers and targets

    Neuroendocrine tumors (NETs) represent a heterogeneous group of diseases with varied natural history and prognosis depending upon the organ of origin and grade of aggressiveness. The most widely used biomarker...

    J. Capdevila, A. Meeker, R. García-Carbonero, K. Pietras… in Cancer and Metastasis Reviews (2014)

  4. Article

    Open Access

    MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer

    During breast cancer progression, transforming growth factor-beta (TGF-β) switches from acting as a growth inhibitor to become a major promoter of epithelial-mesenchymal transition (EMT), invasion and metastas...

    J Johansson, T Berg, E Kurzejamska, M-F Pang, V Tabor, M Jansson, P Roswall… in Oncogene (2013)

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  5. No Access

    Article

    Therapeutic efficacy of a DNA vaccine targeting the endothelial tip cell antigen delta-like ligand 4 in mammary carcinoma

    The Notch ligand delta-like ligand 4 (DLL4) is an essential component expressed by endothelial tip cells during angiogenic sprouting. We have described a conceptually novel therapeutic strategy for targeting t...

    B K Haller, A Bråve, E Wallgard, P Roswall, V G Sunkari, U Mattson… in Oncogene (2010)

  6. No Access

    Article

    The uPA/uPAR system regulates the bioavailability of PDGF-DD: implications for tumour growth

    Members of the platelet-derived growth factor (PDGF) family are mitogens for cells of mesenchymal origin and have important functions during embryonic development, blood vessel maturation, fibrotic diseases an...

    M Ehnman, H Li, L Fredriksson, K Pietras, U Eriksson in Oncogene (2009)

  7. No Access

    Article

    Growth factor analysis of low-grade glioma CSF: PDGF and VEGF are not detectable

    Platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2) are involved in the development of grade 2 gliomas. The aim of the present study was to ...

    D. Ribom, A. Larsson, K. Pietras, A. Smits in Neurological Sciences (2003)