Abstract.
Platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2) are involved in the development of grade 2 gliomas. The aim of the present study was to determine the presence of these growth factors in the cerebrospinal fluid (CSF) and to assess their usefulness as biological markers. CSF was collected from 7 adult patients with newly diagnosed supratentorial low-grade gliomas by lumbar puncture and was analysed together with matched serum samples using radioreceptor and enzyme-linked immunosorbant assays. Neither PDGF nor VEGF were detected in the CSF, and FGF-2 was measurable at extremely low concentrations in only 2 of 7 patients. Serum levels were within normal limits. We conclude that these growth factors are not released into the CSF in any significant amounts and are therefore not suitable as biological markers in grade 2 gliomas.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 22 December 2002 / Accepted in revised form: 27 March 2003
Correspondence to: D. Ribom
Rights and permissions
About this article
Cite this article
Ribom, D., Larsson, A., Pietras, K. et al. Growth factor analysis of low-grade glioma CSF: PDGF and VEGF are not detectable. Neurol Sci 24, 70–73 (2003). https://doi.org/10.1007/s100720300075
Issue Date:
DOI: https://doi.org/10.1007/s100720300075