Chirurgisches Forum und DGAV Forum 2009
für experimentelle und klinische Forschung 126. Kongress der Deutschen Gesellschaft für Chirurgie München, 28.04.-01.05.2009
Page
%P
38 Result(s)
-
Article
Passion and commensurability: both are needed for a concurrence of surgery and research
-
Article
Targeting the vasculature of visceral tumors: novel insights and treatment perspectives
Angiogenesis, the formation of new blood vessels from the endothelium of the existing vasculature, describes a crucial process in tumor growth, disease progression, and metastasis. Therefore, the upcoming stra...
-
Article
Long-term outcome after multivisceral and tumor/vascular resection in patients with soft tissue sarcoma
Soft tissue sarcomas (STS) are rare tumors. General treatment is difficult while multimodality treatment strategies are more and more common. In these strategies, surgical resection of the primary tumor is ess...
-
Book and Conference Proceedings
-
Chapter and Conference Paper
Targeted stem cell based RANTES/TK suicide gene-therapy in a murine pancreatic cancer tumour model
Introduction: The influence of tumour associated stromal cells on tumour growth and on the potential to metastasize is already issue of current research [1,2,3]. In preclinical studies of a breas...
-
Chapter and Conference Paper
The hepatotrophic growth factor Augmenter of liver regeneration (ALR) is protective against metabolic damage via the PI3K/AKT pathway
The liver is a highly metabolic organ with a great potential of regeneration. Beside mitogenic signals via hepatotrophic growth factors like EGF (epidermal growth factor), HGF (hepatocyte growth factor) and AL...
-
Chapter and Conference Paper
Tumor stem cell targeted therapy with mTOR inhibitor RAD001 and hedgehog signalling inhibitor Cyclopamine reverts chemoresistance towards 5-Fluorouracil in human pancreatic carcinoma cells
Background: In the present study, we aimed to identify and to eliminate putative cancer stem cells (CSC) within different human pancreatic cancer cell lines as well as within 5-Fluorouracil-resis...
-
Chapter and Conference Paper
The role of Endothelial Cell-Selective Adhesion Molecule (ESAM) for leukocyte migration and vascular permeability during hepatic ischemia-reperfusion
Background: The endothelial receptors that control leukocyte transmigration in the postischemic liver are not identified. This study was designed to investigate the role of endothelial cell selec...
-
Chapter and Conference Paper
Selection of efficient drugs for the therapy of gastrointestinal cancers using the multicellular spheroid model
Advanced gastrointestinal tumors have a poor prognosis and are largely unresponsive to currently available chemotherapeutic drugs. The development of more effective therapies would be aided by better preclinic...
-
Chapter and Conference Paper
Improvement of translational and clinical research introducing quality management
Health care is facing efficiency (quality) problems while costs are exploding. Quality management (QM) therefore becomes a major strategic challenge. Thus, the international QM system ISO9001:2000 was introduc...
-
Chapter and Conference Paper
Overexpression of the gene IFIT3 enhances tumor growth, angiogenesis, metastasing and chemoresistance of the pancreas carcinoma cells
Background: Pancreas carcinoma belongs to one of the most dangerous tumor disease. Therefore it is very important to understand mechanism leading to change of the low angiogenic and low metastati...
-
Chapter and Conference Paper
A phase I/II clinical trial in patients with locally advanced and/or metastatic pancreatic cancer using a combination of low dose chemotherapy and RAD 001
Background: We like to prove with this study concept whether intrinsically resistant locally advanced and/or metastatic pancreatic cancer can be treated with a combination of antiangiogenic thera...
-
Article
Influence of surgical trauma on the mRNA expression of sex hormone receptors in PBMCs in male and female patients
Gender-specific immune responses have been found after trauma-hemorrhage. Male and female sex hormones seem to be responsible for this gender dimorphism. Alterations in sex hormone receptor expression in mice ...
-
Chapter and Conference Paper
Einsatz muriner mesenchymaler Stammzellen zur Expression spenderspezifischer MHC Klasse I Moleküle zur spenderspezifischen Immunsuppression in der allogenen Organtransplantation
Transplantation tolerance is one of the most important issues in organ transplantation. It has previously been shown in murine animal models that pre-treatment of organ recipients with soluble MHC class I (MHC...
-
Chapter and Conference Paper
Einfluss der Immunsuppression auf die Mikrozirkulation: Erste Ergebnisse einer prospektiven Studie an gesunden Probanden und Patienten nach Nierentransplantation
Introduction: Modern immunosuppressives have markedly improved graft survival after solid organ transplantation. However, these substances are associated with negative effects on transplant funct...
-
Book and Conference Proceedings
Chirurgisches Forum 2008
für experimentelle und klinische Forschung 125. Kongress der Deutschen Gesellschaft für Chirurgie Berlin, 22.04. – 25.04.2008
-
Chapter and Conference Paper
Rekombinantes humanes Augmenter of liver regeneration (rhALR) verbessert die Leberregeneration nach Leberresektion an der Ratte
Background: Augmenter of liver regeneration (ALR) is an endogenous protein, which shows increased expression after liver resection but that also acts as a liver specific growth factor. In vitro s...
-
Chapter and Conference Paper
Prädiktion des Therapieansprechens beim kolorektalen Karzinom im multizellulären Sphäroidmodell: Sphero-PCT-Studie
Background: Despite significant advances in conventional therapeutic approaches, the five-year overall survival rate of CRC patients with an intended curative resection (R0) is less than 50 %. Th...
-
Chapter and Conference Paper
Tumorstammzell-gerichtete Therapie mit Rapamycin und Cyclopamin sensitiviert chemotherapieresistente Pankreaskarzinome gegenüber 5-Fluorouracil
Background: The contribution of cancer stem cells (CSC) to pancreatic cancer has not been established yet. Furthermore, the presence of cancer stem cells in chemotherapy-resistant pancreatic canc...
-
Chapter and Conference Paper
Assoziation der MICA/MICB-Allele mit der Progression kolorektaler Karzinome
Introduction: The major histocompatibility complex class I related A (MICA) and MICB molecules are ligands of NKG2D receptors on gamma/delta natural killer cells and CD8aß T cells and mediate hos...
