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  1. No Access

    Article

    Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways

    Loss of tumour suppressor gene function can occur as a result of epigenetic silencing of large chromosomal regions, referred to as long-range epigenetic silencing (LRES), and genome-wide analyses have revealed...

    A R Dallosso, B Øster, A Greenhough, K Thorsen, T J Curry, C Owen, A L Hancock… in Oncogene (2012)

  2. No Access

    Article

    Attenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes

    Aberrant activation of the Wnt signaling pathway is causally involved in the formation of most colorectal cancers (CRCs). Although detailed knowledge exists regarding Wnt-regulated protein-coding genes, much l...

    T Schepeler, A Holm, P Halvey, I Nordentoft, P Lamy, E M Riising… in Oncogene (2012)