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  1. Article

    Open Access

    Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells

    Platinum-based drugs remain as the cornerstone of cancer chemotherapy; however, development of multidrug resistance presents a therapeutic challenge. This study aims at understanding the molecular mechanisms u...

    S Seah, I C C Low, J L Hirpara, K Sachaphibulkij, G Kroemer… in Cell Death & Disease (2015)

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  2. Article

    Open Access

    A novel Osmium-based compound targets the mitochondria and triggers ROS-dependent apoptosis in colon carcinoma

    Engagement of the mitochondrial-death amplification pathway is an essential component in chemotherapeutic execution of cancer cells. Therefore, identification of mitochondria-targeting agents has become an att...

    A Maillet, S Yadav, Y L Loo, K Sachaphibulkij, S Pervaiz in Cell Death & Disease (2013)

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