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  1. Article

    Open Access

    Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells

    Platinum-based drugs remain as the cornerstone of cancer chemotherapy; however, development of multidrug resistance presents a therapeutic challenge. This study aims at understanding the molecular mechanisms u...

    S Seah, I C C Low, J L Hirpara, K Sachaphibulkij, G Kroemer… in Cell Death & Disease (2015)

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  2. Article

    Open Access

    Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer

    Using a screen for Wnt/β-catenin inhibitors, a family of 8-hydroxyquinolone derivatives with in vivo anti-cancer properties was identified. Analysis of microarray data for the lead compound N-((8-hydroxy-7-quinol...

    G S Coombs, A A Schmitt, C A Canning, A Alok, I C C Low, N Banerjee, S Kaur… in Oncogene (2012)

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