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  1. Article

    Open Access

    Activation of surrogate death receptor signaling triggers peroxynitrite-dependent execution of cisplatin-resistant cancer cells

    Platinum-based drugs remain as the cornerstone of cancer chemotherapy; however, development of multidrug resistance presents a therapeutic challenge. This study aims at understanding the molecular mechanisms u...

    S Seah, I C C Low, J L Hirpara, K Sachaphibulkij, G Kroemer… in Cell Death & Disease (2015)

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  2. Article

    LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization

    Certain classes of tumor cells respond favorably to TRAIL due to the presence of cell surface death receptors DR4 and DR5. Despite this preferential sensitivity, resistance to TRAIL remains a clinical problem ...

    T W Poh, S Huang, J L Hirpara, S Pervaiz in Cell Death & Differentiation (2007)

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  3. Article

    Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria

    At least two mechanisms of early cytosolic acidification during apoptotic signaling have been described, one that involves caspase 8 activation downstream of receptor ligation and another dependent on mitochon...

    M-V Clément, J L Hirpara, S Pervaiz in Cell Death & Differentiation (2003)

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