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Article
Open AccessCorrelation of PD-L1 expression on tumour cells between diagnostic biopsies and surgical specimens of lung cancer in real life with respect to biopsy techniques and neoadjuvant treatment
Programmed death-ligand 1 (PD-L1) testing is performed mainly on biopsy specimens in patients with advanced lung cancer. It is questionable whether the small amount of tissue analysed in biopsies may represent...
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Article
Open AccessDifferential expression of circulating miRNAs after alemtuzumab induction therapy in lung transplantation
Alemtuzumab is a monoclonal antibody targeting CD52, used as induction therapy after lung transplantation (LTx). Its engagement produces a long-lasting immunodepletion; however, the mechanisms driving cell rec...
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Grenzen der pulmonalen Metastasektomie
Die pulmonale Metastasektomie ist heute ein fixer Bestandteil der interdisziplinären Behandlung von Krebspatienten. Die Verschränkung lokaler, chirurgischer und systemisch-chemotherapeutischer Therapiekonzepte...
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Article
High levels of lung resident CD4+CD28null cells in COPD: implications of autoimmunity
Chronic obstructive pulmonary disease (COPD) is a worldwide burden and a major cause of death. Pathogenetic mechanisms underlying the disease are still largely unknown. However, a continuous toxic injury due t...
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Article
Open AccessSecretome of apoptotic peripheral blood cells (APOSEC) attenuates microvascular obstruction in a porcine closed chest reperfused acute myocardial infarction model: role of platelet aggregation and vasodilation
Although epicardial blood flow can be restored by an early intervention in most cases, a lack of adequate reperfusion at the microvascular level is often a limiting prognostic factor of acute myocardial infarc...
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Article
Open AccessSerum 20S proteasome is elevated in patients with renal cell carcinoma and associated with poor prognosis
To date, no reliable serum marker for clear cell renal cell carcinoma (CCRCC) is available. The aim of this study was to evaluate the putative significance of circulating 20S proteasome levels.
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Article
Pulmonary metastasectomy
BACKGROUND: The major obstacle in curing cancer is the limited ability to prevent and treat metastatic disease. Pulmonary metastasectomy is now a standard treatment option in carefully selected cases. With the...
