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Article
Open AccessReduced adipocyte glutaminase activity promotes energy expenditure and metabolic health
Glutamine and glutamate are interconverted by several enzymes and alterations in this metabolic cycle are linked to cardiometabolic traits. Herein, we show that obesity-associated insulin resistance is charact...
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Article
Open AccessAn integrated single cell and spatial transcriptomic map of human white adipose tissue
To date, single-cell studies of human white adipose tissue (WAT) have been based on small cohort sizes and no cellular consensus nomenclature exists. Herein, we performed a comprehensive meta-analysis of publi...
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Article
Open AccessThe long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase
The pleiotropic function of long noncoding RNAs is well recognized, but their direct role in governing metabolic homeostasis is less understood. Here, we describe a human adipocyte-specific lncRNA, ADIPINT, th...
