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Article
Open AccessThe long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase
The pleiotropic function of long noncoding RNAs is well recognized, but their direct role in governing metabolic homeostasis is less understood. Here, we describe a human adipocyte-specific lncRNA, ADIPINT, th...
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Article
Open AccessImpaired phosphocreatine metabolism in white adipocytes promotes inflammation
The mechanisms promoting disturbed white adipocyte function in obesity remain largely unclear. Herein, we integrate white adipose tissue (WAT) metabolomic and transcriptomic data from clinical cohorts and find...
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Article
Maternal high-fat diet during suckling programs visceral adiposity and epigenetic regulation of adipose tissue stearoyl-CoA desaturase-1 in offspring
The lactation-suckling period is critical for white adipose tissue (WAT) development. Early postnatal nutrition influences later obesity risk but underlying mechanisms remain elusive. Here, we tested whether a...
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Article
Open AccessExpression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice
Maternal obesity impacts fetal growth and pregnancy outcomes. To counteract the deleterious effects of obesity on fertility and pregnancy issue, preconceptional weight loss is recommended to obese women. Wheth...
