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Open AccessAuthor Correction: Identification of markers for migrasome detection
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Article
Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer
Kras-activating mutations display the highest incidence in pancreatic ductal adenocarcinoma. Pancreatic inflammation accelerates mutant Kras-driven tumorigenesis in mice, suggesting high selectivity in the cel...
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Article
Open AccessPancreatic cancer-educated macrophages protect cancer cells from complement-dependent cytotoxicity by up-regulation of CD59
Tumor-associated macrophages (TAMs) are versatile immune cells that promote a variety of malignant behaviors of pancreatic cancer. CD59 is a GPI-anchored membrane protein that prevents complement activation by...
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Article
Author Correction: Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively delineate the PDAC intra-tumoral heter...
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Article
Open AccessIdentification of markers for migrasome detection
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Article
Open AccessDiscovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration
Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for...
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Open AccessDapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation
Autophagy is an intracellular degradation process to clear up aggregated proteins or aged and damaged organelles. The Beclin1-Vps34-Atg14L complex is essential for autophagosome formation. However, how the com...
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Open AccessAtg5 regulates late endosome and lysosome biogenesis
Autophagy is an evolutionarily conserved lysosome-based degradation process. Atg5 plays a very important role in autophagosome formation. Here we show that Atg5 is required for biogenesis of late endosomes and...
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Article
Termination of autophagy and reformation of lysosomes regulated by mTOR
During autophagy, double-membrane autophagosomes sequester intracellular components and then fuse with lysosomes to form autolysosomes in which cargo is degraded. Under starvation conditions, the nutrient-resp...
