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Article
Open AccessArtificial intelligence-based radiographic extent analysis to predict tuberculosis treatment outcomes: a multicenter cohort study
Predicting outcomes in pulmonary tuberculosis is challenging despite effective treatments. This study aimed to identify factors influencing treatment success and culture conversion, focusing on artificial inte...
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Article
Open AccessDiffusing capacity as an independent predictor of acute exacerbations in chronic obstructive pulmonary disease
A weak correlation between diffusing capacity of the lung for carbon monoxide (DLCO) and emphysema has been reported. This study investigated whether impaired DLCO in chronic obstructive pulmonary disease (COPD) ...
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Article
Open AccessClinical outcomes of long-term inhaled combination therapies in patients with bronchiectasis and airflow obstruction
Few studies have reported which inhaled combination therapy, either bronchodilators and/or inhaled corticosteroids (ICSs), is beneficial in patients with bronchiectasis and airflow obstruction. Our study compa...
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Article
Open AccessThe factors associated with mortality and progressive disease of nontuberculous mycobacterial lung disease: a systematic review and meta-analysis
This systematic review and meta-analysis aimed to comprehensively evaluate the factors associated with mortality and progressive disease in NTM-LD patients. We conducted a literature search to identify the eli...
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Article
Anti-inflammatory effects of Athyrium yokoscense extract via inhibition of the Erk1/2 and NF-κB pathways in bisphenol A-stimulated A549 cells
Bisphenol A is an environmental endocrine disruptor that has similar functions to estrogen in humans. However, few studies have investigated pulmonary inflammation induced by BPA, and the effect of Athyrium yokos...
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Article
Open AccessTreatment shortening of drug-sensitive pulmonary tuberculosis using high-dose rifampicin for 3 months after culture conversion (Hi-DoRi-3): a study protocol for an open-label randomized clinical trial
The standard treatment regimen for drug-sensitive tuberculosis (TB), comprising four companion drugs, requires a minimum duration of 6 months, and this lengthy treatment leads to poor adherence and increased t...
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Article
Open AccessAssociation between oxygen saturation level during bronchoscopy and post-bronchoscopy adverse events: a retrospective cohort study
Flexible bronchoscopy is widely used to diagnose and treat various respiratory diseases. However, caution is warranted for post-bronchoscopy adverse events. Although desaturation frequently occurs during bronc...
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Article
Open AccessPeripheral lymphocyte count as a surrogate marker of immune checkpoint inhibitor therapy outcomes in patients with non-small-cell lung cancer
Degree of expression of programmed death-ligand 1 (PD-L1) is related with Immune check point inhibitors (ICIs) response but it needs sufficient tumor tissue. There is unmet need for easily accessible and progn...
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Article
Open AccessThe clinical impact of drug-induced hepatotoxicity on anti-tuberculosis therapy: a case control study
There are limited data available on whether drug-induced hepatotoxicity (DIH) affects the clinical outcomes of tuberculosis (TB) treatment. We explored the effects of DIH on the clinical course and outcomes of...
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Article
Open AccessDiagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome
We aimed to evaluate whether serum activin-A levels are elevated and have any value in predicting severity and prognosis in acute respiratory distress syndrome (ARDS).
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Article
Open AccessSubstitution of ethambutol with linezolid during the intensive phase of treatment of pulmonary tuberculosis: study protocol for a prospective, multicenter, randomized, open-label, phase II trial
Linezolid, an oxazolidinone, substantially improves treatment outcomes of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. We started a trial to test whether the use of linezolid i...
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Article
Open AccessThe regional association between bronchiectasis and lung cancer in chest CT
Limited studies have examined the association between lung cancer and bronchiectasis (BE). This study evaluated the regional association between BE and lung cancer by analyzing the lobar location of lung cance...
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Article
A protein chip based inhibitor screening for influenza neuraminidases: the importance of glycan-specific recognition
A protein chip assay system based on a specific carbohydrate-protein interaction has been constructed for the identification of chemical inhibitors of influenza neuraminidase. The devised chip is composed of t...
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Article
Analysis of Plk1-Bora interaction using a protein chip system
We investigated the interaction between Polo-Box Domain (PBD) of polo-like kinase 1 (Plk1) and Bora peptide based on protein-protein interactions using the Proteochip (Proteogen, Korea) technology. Plk-1 prote...
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Article
Expression of secretory leukocyte protease inhibitor in middle ear cholesteatoma
Secretory leukocyte protease inhibitor (SLPI) is a cationic protein and a member of the innate immunity-associated protein family. The main function of SLPI is to protect local tissue against the detrimental c...
