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Article
A chitosan/alginate coated nano-liposome to improve intestinal absorption of curcumin for oral administration
Attempts to improve low absorption and rapid metabolic conversion of curcumin were made by develo** curcumin-loaded bilayer nanoliposomes coated with chitosan and alginate for intestinal-specific drug delive...
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Article
Open AccessThe clinical impact of drug-induced hepatotoxicity on anti-tuberculosis therapy: a case control study
There are limited data available on whether drug-induced hepatotoxicity (DIH) affects the clinical outcomes of tuberculosis (TB) treatment. We explored the effects of DIH on the clinical course and outcomes of...
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Article
Open AccessDeflection induced cellular focal adhesion and anisotropic growth on vertically aligned silicon nanowires with differing elasticity
Cellular adhesion and growth on substrates with differing surface topography are known to induce unusual cell behaviors. Here, we investigated the adhesion and growth of human embryonic kidney 293T cells on ve...
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Article
Alleviating effects of Opuntia ficus indica extracts on psychomotor alterations induced by ethanol in rats
Effects of Opuntia ficus indica (OFI) extracts on ethanol-induced psychomotor alterations were studied using Sprague-Dawley rats orally administered 4 g/kg of ethanol (EtOH group) or distilled water (control grou...
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Article
Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice, possibly through modulation of the GABAA receptor
Cirsium japonicum (CJ) has been shown to possess antidepressant-like properties. In the present study, we sought to identify which constituent of CJ might be responsible for its antidepressant ef...
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Article
The involvement of magnoflorine in the sedative and anxiolytic effects of Sinomeni Caulis et Rhizoma in mice
The present study seeks to evaluate the sedative and anxiolytic effects of the 70 % ethanol extract of Sinomeni Caulis et Rhizoma (SR). The extract was orally administered to mice at dosages of 25, 50, 100, 200 o...
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Article
The ameliorating effects of 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one, an oroxylin A derivative, against memory impairment and sensorimotor gating deficit in mice
We previously reported that oroxylin A, a γ-aminobutyric acid A (GABAA) receptor antagonist, ameliorates drugs-induced memory impairments. We synthesized several oroxylin A derivatives in efforts to find a substa...
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Article
Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro
In previous studies we have demonstrated that the γ-aminobutryic acid-A (GABA-A) receptor antagonist oroxylin A has an awakening effect and it also represses ADHD-like behaviors (hyperactivity, impulsivity and...
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Article
Methylphenidate treatment in the spontaneously hypertensive rat: influence on methylphenidate self-administration and reinstatement in comparison with Wistar rats
Methylphenidate is a psychostimulant given for extended periods of time as a treatment of attention-deficit/hyperactivity disorder (ADHD). The long-term effects of the drug are not yet known, and it is specula...
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Article
Is the anti-stress effect of vitamin C related to adrenal gland function in rat?
The aim of this study was to investigate whether vitamin C influences the stress response system of the adrenal gland. Adrenalectomized (ADX) rats and non-ADX rats were administered vitamin C and were subjecte...
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Article
Vitamin C supplementation alleviates electroshock stress but not restraint stress in ICR mice
The aim of this study was to investigate what kind of stress vitamin C could alleviate. Experiments were performed using male ICR mice. Vitamin C (1, 5, 25, and 100 mg/kg) was administered orally daily for 7 d...
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Article
Inhibition of intestinal motility by the putative BKCa channel opener LDD175
LDD175 (4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid) is a benzofuroindole compound characterized previously as a potent opener of the large conductance calcium activated (BKCa) ch...