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  1. Article

    Open Access

    Mitochondrial DNA Copy Number as a Biomarker for Guiding Adjuvant Chemotherapy in Stages II and III Colorectal Cancer Patients with Mismatch Repair Deficiency: Seeking Benefits and Avoiding Harms

    Colorectal cancer (CRC) patients with mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) status are conventionally perceived as unresponsive to adjuvant chemotherapy (ACT). The mitochondria...

    Mian Chen PhD, Shenghe Deng MD, Yinghao Cao MD, Jun Wang PhD… in Annals of Surgical Oncology (2024)

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    Article

    ASO Visual Abstract: Menstrual Phase and Menopausal Status Classification of Benign Breast Tissue Using Hormone-Regulated Gene Expression and Histomorphology: A Validation Study

    Omid Hosseini MD, Jun Wang PhD, Oukseub Lee PhD… in Annals of Surgical Oncology (2023)

  3. No Access

    Article

    Menstrual Phase and Menopausal Status Classification of Benign Breast Tissue Using Hormone-Regulated Gene Expression and Histomorphology: A Validation Study

    The validation of breast cancer risk biomarkers in benign breast samples (BBS) is a long-sought goal, hampered by the fluctuation of gene and protein expression with menstrual phase (MP) and menopausal status ...

    Omid Hosseini BSA, Jun Wang PhD, Oukseub Lee PhD… in Annals of Surgical Oncology (2023)

  4. No Access

    Article

    Strategic Shift of Statistical Review on Data Quality Assessment for New Drug Applications in China

    Data quality is critical for clinical trials to obtain robust conclusions about drug safety and efficacy evaluation. Effective data quality evaluation has been one of the major obstacles to new drug approvals ...

    Jun Wang PhD, Gang Wang PhD, Min Li PhD… in Therapeutic Innovation & Regulatory Science (2019)

  5. No Access

    Article

    Genetic Determinants of Nipple Aspiration Fluid Yield

    Nipple aspiration fluid (NAF) is a non-invasively-acquired biosample that can provide a window into the breast environment, but NAF yield is highly variable. Its determinants must be better understood for stud...

    Ali Shidfar MD, Jun Wang PhD, Elliot Wiesenfeld BS… in Annals of Surgical Oncology (2016)

  6. No Access

    Article

    Hippo/Yap Signaling in Cardiac Development and Regeneration

    The heart has historically been considered to be a non-regenerative organ. Recent insights have suggested that cardiomyocytes have a small but measurable ability to regenerate. Moreover, recent work has also s...

    Yang **ao MB, MS, John Leach BS… in Current Treatment Options in Cardiovascula… (2016)

  7. No Access

    Article

    Fetuses Delivered Following Preterm Prelabor Rupture of the Membranes Are Capable of Stimulating a Proinflammatory Response in Endothelial Cells

    Preterm premature rupture of the membranes (PROM) has been attributed to ascending infection and a choriodecidual inflammatory response (ie, on the maternal side). However, on the fetal side those most at risk...

    Neil Athayde MBBS, Jun Wang PhD, **n Wang MS… in The Journal of the Society for Gynecologic… (2005)

  8. No Access

    Article

    Association of Umbilical Placental Vascular Disease With Fetal Acute Inflammatory Cytokine Responses

    We examined the hypothesis tha fetal proinflammatory cytokine release is a feature of placental vascular disease causing fetal compromise. We measured the concentrations of fetal proinflammaory cytokines inter...

    Brian Trudinger MD, Jun Wang PhD… in The Journal of the Society for Gynecologic… (2002)