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Article
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
Hidewaki Nakagawa and colleagues report the whole-genome sequencing of 27 hepatocellular carcinomas. They find that chromatin regulators were mutated in approximately 50% of tumors.
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Article
High-resolution characterization of a hepatocellular carcinoma genome
Tatsuhiro Shibata and colleagues report the sequencing of a hepatocellular carcinoma. The authors identified 63 somatic non-synonymous substitutions and 22 somatic chromosomal rearrangements in this liver tumor.
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Article
Open AccessCollection of Macaca fascicularis cDNAs derived from bone marrow, kidney, liver, pancreas, spleen, and thymus
Consolidating transcriptome data of non-human primates is essential to annotate primate genome sequences, and will facilitate research using non-human primates in the genomic era. Macaca fascicularis is a macaque...
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Article
Open AccessExtensive expansion and diversification of the chemokine gene family in zebrafish: Identification of a novel chemokine subfamily CX
The chemokine family plays important roles in cell migration and activation. In humans, at least 44 members are known. Based on the arrangement of the four conserved cysteine residues, chemokines are now class...
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Article
Open AccessLarge-scale analysis of Macaca fascicularis transcripts and inference of genetic divergence between M. fascicularis and M. mulatta
Cynomolgus macaques (Macaca fascicularis) are widely used as experimental animals in biomedical research and are closely related to other laboratory macaques, such as rhesus macaques (M. mulatta). We isolated 85,...
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Article
Open AccessCynomolgus monkey testicular cDNAs for discovery of novel human genes in the human genome sequence
In order to contribute to the establishment of a complete map of transcribed regions of the human genome, we constructed a testicular cDNA library for the cynomolgus monkey, and attempted to find novel transcr...
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Article
Prediction of unidentified human genes on the basis of sequence similarity to novel cDNAs from cynomolgus monkey brain
The complete assignment of the protein-coding regions of the human genome is a major challenge for genome biology today. We have already isolated many hitherto unknown full-length cDNAs as orthologs of unident...
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Article
Assignment of a human autoimmune antigen, p80-coilin gene to chromosome 17q21-q23 and of its possible pseudogene to chromosome 14
In order to determine the chromosomal locations of an autoimmune antigen, the coilin gene and its pseudogene, we amplified the segments of the two genes by the polymerase chain reaction (PCR) and screened a pa...
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Article
The sequence around the 5′ end of the fibroin gene from the wild silkworm, Bombyx mandarina, and comparison with that of the domesticated species, B. mori
The fibroin gene of the wild silkworm Bombyx mandarina was identified through hybridization with the fibroin DNA of the domesticated species, B. mori. Using their cross homology, we isolated the clone carrying th...
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Article
Characterization of the cloned ribosomal DNA of tobacco chloroplasts
A physical map of the cloned ribosomal DNA of tobacco chloroplasts was constructed by cleavage with several restriction endonucleases and hybridization of the restriction fragments with labeled 16S and 23S rRN...
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Article
Molecular cloning of tobacco chloroplast ribosomal RNA genes
Tobacco chloroplast ribosomal RNAs were shown to be hybridized with two EcoRI fragments of tobacco chloroplast DNA. These DNA fragments having molecular weights of 1.9x106 and 2.8x106 daltons were cloned using th...
