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Article
Social media has become a mainstream source of medical information for patients with rheumatic diseases: a cross-sectional survey of patients
This study analyzed the status of medical information acquisition through social media (SM) and its impact on healthcare utilization among patients with rheumatic diseases (RDs) who visited the rheumatology de...
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Article
Pretreatment C-reactive protein-to-albumin ratio predicts clinical outcomes in patients with peripheral T-cell lymphoma
Peripheral T-cell lymphoma (PTCL) is an aggressive and heterogenous T-cell lymphoid malignancy. The prognostic value of C-reactive protein-to-albumin ratio (CAR) has never been assessed in PTCL.
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Article
Bayesian Mixture Model of Extended Redundancy Analysis
Extended redundancy analysis (ERA), a generalized version of redundancy analysis (RA), has been proposed as a useful method for examining interrelationships among multiple sets of variables in multivariate lin...
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Article
Open AccessCellular direct conversion by cell penetrable OCT4-30Kc19 protein and BMP4 growth factor
The number of patients suffering from osteoporosis is increasing as the elderly population increases. The demand for investigating bone regeneration strategies naturally arises. One of the approaches to induce...
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Article
Long-term monitoring and risk assessment of N-nitrosamines in the finished water of drinking water treatment plants in South Korea
Approximately 99.1% of South Koreans have access to drinkable tap water from river basins. Due to such a high access rate, the South Korean government has been running, since 2013, a long-term program for moni...
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Article
AI-based improvement in lung cancer detection on chest radiographs: results of a multi-reader study in NLST dataset
Assess if deep learning–based artificial intelligence (AI) algorithm improves reader performance for lung cancer detection on chest X-rays (CXRs).
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Article
Prediction of clinical outcomes through assessment of sarcopenia and adipopenia using computed tomography in adult patients with acute myeloid leukemia
Sarcopenia and adipopenia have prognostic significance in cancer. Analysis of a single abdominal computed tomography (CT) section at the third lumbar vertebra has been widely adopted for this purpose. The appr...
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Article
Open AccessHigh level of pre-treatment C-reactive protein to albumin ratio predicts inferior prognosis in diffuse large B-cell lymphoma
The C-reactive protein-to-albumin ratio (CAR) has not been assessed in diffuse large B cell lymphoma (DLBCL, the most common non-Hodgkin lymphoma). This retrospective study evaluated the prognostic value of CA...
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Article
Non-viral Gene Disruption by CRISPR/Cas9 Delivery Using Cell-permeable and Protein-stabilizing 30Kc19 Protein
CRISPR/Cas9 system has served a new insight in genome editing of eukaryotes, including human cells. In this system, delivery of Cas9 nuclease with guide RNA has been central challenge in develo** safe and ef...
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Article
Association Between Sarcopenic Obesity and Pulmonary Function in Korean Elderly: Results from the Korean National Health and Nutrition Examination Survey
Although body composition is related to lung function, few studies have reported the effects of sarcopenic obesity on lung function. Thus, the aim of this study was to investigate the associations between lung...
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Article
Efficient Production of Cell-permeable Oct4 Protein Using 30Kc19 Protein Originating from Silkworm
Oct4 is a transcription factor (TF), which works as a transcriptional activator and plays an essential role in reprogramming or direct conversion of somatic cells. Many strategies have been reported to transdu...
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Article
Gender Differences in HIV/HSV-2: Evidence from a School Support Randomized Controlled Trial Among Orphaned Adolescents in Kenya
Women and girls are disproportionately affected by HIV and other sexually transmitted infections (STIs) such as Herpes Simplex Virus type-2 (HSV-2) in Sub-Saharan Africa (SSA). Given this gender disparity and ...
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Article
Bayesian curve fitting and clustering with Dirichlet process mixture models for microarray data
In the field of molecular biology, it is often of interest to analyze microarray data for clustering genes based on similar profiles of gene expression to identify genes that are differentially expressed under...
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Article
Open AccessTwo high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia
Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated ca...
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Article
Estimation of complex effect-size distributions using summary-level statistics from genome-wide association studies across 32 complex traits
We developed a likelihood-based approach for analyzing summary-level statistics and external linkage disequilibrium information to estimate effect-size distributions of common variants, characterized by the pr...
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Article
Open AccessComparison of intraoperative handling and wound healing between (NEOSORB® plus) and coated polyglactin 910 suture (NEOSORB®): a prospective, single-blind, randomized controlled trial
Coated polyglactin 910 suture with chlorhexidine (NEOSORB® Plus) has recently been developed to imbue the parent suture with antibacterial activity against organisms that commonly cause surgical site infection...
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Article
An unusual continuous paramagnetic-limited superconducting phase transition in 2D NbSe 2
Time reversal and spatial inversion are two key symmetries for conventional Bardeen–Cooper–Schrieffer (BCS) superconductivity 1 . Breaking inversion symmetry can lead to mixed-pa...
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Article
Open AccessEvolution of Weyl orbit and quantum Hall effect in Dirac semimetal Cd3As2
Owing to the coupling between open Fermi arcs on opposite surfaces, topological Dirac semimetals exhibit a new type of cyclotron orbit in the surface states known as Weyl orbit. Here, by lowering the carrier d...
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Article
Promotive effects of human induced pluripotent stem cell-conditioned medium on the proliferation and migration of dermal fibroblasts
Fibroblasts are a major cell type in the dermis. When skin is wounded in various ways such as by abrasions, cuts or diabetic ulcer, proliferation and migration of dermal fibroblasts is necessary for cutaneous ...
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Article
Protective effects of silkworm hemolymph extract and its fractions on UV-induced photoaging
Ultraviolet (UV) irradiation induces skin photoaging by generating reactive oxygen species (ROS). ROS caused by UV-irradiation results in loss of skin cells and degradation of extracellular matrix. A number of...
