22 Result(s)

Article

Clinical associations with a polygenic predisposition to benign lower white blood cell counts

Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical conse...

Jonathan D. Mosley, John P. Shelley, Alyson L. Dickson… in Nature Communications (2024)

Article

Genome-wide association study between copy number variation and feeding behavior, feed efficiency, and growth traits in Nellore cattle

Feeding costs represent the largest expenditures in beef production. Therefore, the animal efficiency in converting feed in high-quality protein for human consumption plays a major role in the environmental im...

Lorena F. Benfica, Luiz F. Brito, Ricardo D. do Bem, Henrique A. Mulim… in BMC Genomics (2024)

Article

Genomic variants exclusively identified in children with birth defects and concurrent malignant tumors predispose to cancer development

Children with birth defects (BD) express distinct clinical features that often have various medical consequences, one of which is predisposition to the development of cancers. Identification of the underlying ...

Yichuan Liu, Hui-Qi Qu, **ao Chang, Frank D Mentch, Haijun Qiu… in Molecular Cancer (2023)

Article

Metabolomic profiling for dyslipidemia in pediatric patients with sickle cell disease, on behalf of the IHCC consortium

Previous study has shown that dyslipidemia is common in patients with Sickle cell disease (SCD) and is associated with more serious SCD complications.

Hui-Qi Qu, Joseph Glessner, **gchun Qu, Frank Mentch, Ian Campbell… in Metabolomics (2022)

Article

Identification of risk variants related to malignant tumors in children with birth defects by whole genome sequencing

Children with birth defects (BD) are more likely to develop cancer and the increased risk of cancer persists into adulthood. Prior population-based assessments have demonstrated that even non-chromosomal BDs a...

Yichuan Liu, Hui-Qi Qu, **ao Chang, Frank D Mentch, Haijun Qiu… in Biomarker Research (2022)

Article

Burden of rare coding variants reveals genetic heterogeneity between obese and non-obese asthma patients in the African American population

Asthma is a complex condition largely attributed to the interactions among genes and environments as a heterogeneous phenotype. Obesity is significantly associated with asthma development, and genetic studies ...

Yichuan Liu, Hui-Qi Qu, **gchun Qu, **ao Chang, Frank D. Mentch… in Respiratory Research (2022)

Article

Application of deep learning algorithm on whole genome sequencing data uncovers structural variants associated with multiple mental disorders in African American patients

Mental disorders present a global health concern, while the diagnosis of mental disorders can be challenging. The diagnosis is even harder for patients who have more than one type of mental disorder, especiall...

Yichuan Liu, Hui-Qi Qu, Frank D. Mentch, **gchun Qu, **ao Chang… in Molecular Psychiatry (2022)

Article

Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci

Type 1 diabetes (T1D) patients with low genetic risk scores (GRS) may be non-autoimmune or autoimmune mediated by other genetic loci. The T1D-GRS2 provides us an opportunity to look into the genetic architectu...

Hui-Qi Qu, **gchun Qu, Jonathan Bradfield, Luc Marchand… in Communications Biology (2021)

Article

Mitochondrial DNA haplogroups and risk of attention deficit and hyperactivity disorder in European Americans

Although mitochondrial dysfunction has been implicated in the pathophysiology of attention deficit and hyperactivity disorder ADHD, the role of mitochondrial DNA (mtDNA) has not been extensively investigated. ...

**ao Chang, Yichuan Liu, Frank Mentch, Joseph Glessner… in Translational Psychiatry (2020)

Article

Non-coding structural variation differentially impacts attention-deficit hyperactivity disorder (ADHD) gene networks in African American vs Caucasian children

Previous studies of attention-deficit hyperactivity disorder (ADHD) have suggested that structural variants (SVs) play an important role but these were mainly studied in subjects of European ancestry and focus...

Yichuan Liu, **ao Chang, Huiqi Qu, Joseph Glessner, Lifeng Tian… in Scientific Reports (2020)

Article

Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk

MYCN amplification and 11q deletion are two inversely correlated prognostic factors of poor outcome in neuroblastoma. Here we identify common variants at 11q22.2 within MMP20 that associa...

**ao Chang, Yan Zhao, Cui** Hou, Joseph Glessner, Lee McDaniel… in Nature Communications (2017)

Article

Erratum to: Copy number variation in CEP57L1 predisposes to congenital absence of bilateral ACL and PCL ligaments

Yichuan Liu, Yun Li, Michael E. March, Kenny Nguyen, Kexiang Xu… in Human Genomics (2016)

Article

Genome-wide association study reveals two loci for serum magnesium concentrations in European-American children

Magnesium ions are essential to the basic metabolic processes in the human body. Previous genetic studies indicate that serum magnesium levels are highly heritable and a few genetic loci have been reported inv...

**ao Chang, Joseph Glessner, Adrienne Tin, ** Li, Yiran Guo, Zhi Wei… in Scientific Reports (2015)

Article

Copy number variation in CEP57L1 predisposes to congenital absence of bilateral ACL and PCL ligaments

Absence of the anterior (ACL) or posterior cruciate ligament (PCL) are rare congenital malformations that result in knee joint instability, with a prevalence of 1.7 per 100,000 live births and can be associate...

Yichuan Liu, Yun Li, Michael E. March, Kenny Nguyen, Kexiang Xu… in Human Genomics (2015)

Article

The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism

Although multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules ...

Dexter Hadley, Zhi-liang Wu, Charlly Kao, Akshata Kini… in Nature Communications (2014)

Article

GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus

We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel l...

Patrick Sleiman, Dai Wang, Joseph Glessner, Dexter Hadley… in Scientific Reports (2013)