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Article
Open AccessSomatic PRKAR1A mutation in sporadic atrial myxoma with cerebral parenchymal metastases: a case report
Atrial myxomas are generally considered benign neoplasms. The majority of tumors are sporadic and less than 10% are associated with an autosomal dominant condition known as the Carney complex, which is most of...
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Article
Open AccessMinocycline mitigates the effect of neonatal hypoxic insult on human brain organoids
Neonatal hypoxic injury (NHI) is a devastating cause of disease that affects >60% of babies born with a very low birth weight, resulting in significant morbidity and mortality, including life-long neurological...
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Article
Open AccessENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy
Diseases of ectopic calcification of the vascular wall range from lethal orphan diseases such as generalized arterial calcification of infancy (GACI), to common diseases such as hardening of the arteries assoc...
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Article
CD44 regulates vascular endothelial barrier integrity via a PECAM-1 dependent mechanism
Vascular integrity is a critical parameter in normal growth and development. Loss of appropriate vascular barrier function is present in various immune- and injury-mediated pathological conditions. CD44 is an ...
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Article
GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions
The neurogenic areas of the brain are highly organized structures in which there is dynamic reciprocal modulation of neural stem cells (NSC) and microvascular endothelial cells (BEC) resulting in control of ne...
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Chapter
Angiogenesis, the Neurovascular Niche and Neuronal Reintegration After Injury
Injury to the central nervous system caused by traumatic brain and/or spinal cord injury, stroke, autoimmune and neurodegenerative diseases and hypoxia all evoke a repair process involving angio-genesis and ne...
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Article
Maternal Diabetes: Effects on Embryonic Vascular Development—A Vascular Endothelial Growth Factor-A-mediated Process
Major congenital malformations, many of which result from abnormal cardiovascular patterning, remain the leading cause in infant mortality and morbidity. Targeted mutations of several genes (including VEGF and...
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Article
Type IV collagen modulates angiogenesis and neovessel survival in the rat aorta model
Type IV collagen is a major basement membrane component that has been implicated in the regulation of angiogenesis. The purpose of this study was to evaluate the effect of type IV collagen on the angiogenic re...
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Article
Arrest of Vascular Development Correlates with the Failure of Platelet Endothelial Factor-1 (PECAM-1) Dephosphorylation in Hyperglycemia-Induced Embryopathy • 366
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Article
An in vitro three-dimensional coculture model of cerebral microvascular angiogenesis and differentiation
The microvasculature of the develo** brain is plastic and responds differently to the many insults associated with preterm birth.
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Article
Human capillary endothelial cells from abdominal wall adipose tissue: Isolation using an anti-pecam antibody
We have developed a novel isolation technique for harvesting human capillary endothelial cells. We compared the use of eitherUlex Europaeus Agglutinin (UEA) lectin or anti-platelet endothelial cell adhesion molec...
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Chapter
Interactions of Matrix Components and Soluble Factors in Vascular Responses to Injury
The vascular system is lined by mitotically quiescent but metabolically active endothelial cells, which in addition to having a broad range of metabolic activities, provide a nonthrombogenic surface for blood ...
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Chapter
Endothelial Cell — Extracellular Matrix Interactions: Modulation of Vascular Cell Phenotype by Matrix Components and Soluble Factors
The vessel wall is comprised of several different cell populations residing in and on a complex extracellular matrix. Each of the resident cell types has diverse functions and morphologies and each has a role ...
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Article
Modulation of actin mRNAs in cultured vascular cells by matrix components and TGF-β1
Alpha-smooth muscle actin is currently considered a marker of smooth muscle cell differentiation. However, during various physiologic and pathologic conditions, it can be expressed, sometimes only transiently,...
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Chapter
Endothelial Cell-Extracellular Matrix Interactions
The role of extracellular matrix as a modulator of cell behavior is widely accepted and is currently under intensive study by a number of investigators using diverse cell, tissue, and organ culture systems.10,34 ...
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Chapter
Angiogenesis
Angiogenesis, the formation of new vessels during development, in response to injury and tumor angiogenic factors is a dynamic process that is controlled by many diverse, sometimes complex factors acting toget...
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Chapter
Angiogenesis
The response of vascularized tissue to injury depends in part upon complex and diverse micro vascular endothelial cell activities. Although various aspects of the inflammatory response have been known and writ...
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Article
Cryopreserved Dermis is an Ideal Substrate for the Engraftment and Maturation of Human Epidermal Keratinocyte Cultures
The ideal replacement for skin damaged by full-thickness injury is the split-thickness autograft. In extensive burns, use of autograft is limited by the availability of uninjured donor skin. This limitation ca...
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Article
Endothelial growth factors and extracellular matrix regulate DNA synthesis through modulation of cell and nuclear expansion
Studies were carried out to analyze the mechanism by which extracellular matrix (ECM) molecules and soluble growth factors interplay to control capillary endothelial cell growth. Bovine adrenal capillary endot...
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Chapter
The Extracellular Matrix as a Modulator of Angiogenesis
Endothelium is comprised of heterogeneous cell populations residing in a variety of vascular beds. The endothelial cells resident in these diverse vascular beds or regions exhibit a broad range of diversity in...
