17 Result(s)

Article

Author Correction: The evolutionary history of 2,658 cancers

Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C. Dentro… in Nature (2023)

Article

Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer

Lina Sieverling, Chen Hong, Sandra D. Koser, Philip Ginsbach… in Nature Communications (2022)

Article

Mutational mechanisms sha** the coding and noncoding genome of germinal center derived B-cell lymphomas

B cells have the unique property to somatically alter their immunoglobulin (IG) genes by V(D)J recombination, somatic hypermutation (SHM) and class-switch recombination (CSR). Aberrant targeting of these mecha...

Daniel Hübschmann, Kortine Kleinheinz, Rabea Wagener, Stephan H. Bernhart… in Leukemia (2021)

Article

Framework for quality assessment of whole genome cancer sequences

Bringing together cancer genomes from different projects increases power and allows the investigation of pan-cancer, molecular mechanisms. However, working with whole genomes sequenced over several years in di...

Justin P. Whalley, Ivo Buchhalter, Esther Rheinbay… in Nature Communications (2020)

Article

Genomic footprints of activated telomere maintenance mechanisms in cancer

Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part ...

Lina Sieverling, Chen Hong, Sandra D. Koser, Philip Ginsbach… in Nature Communications (2020)

Article

The evolutionary history of 2,658 cancers

Cancer develops through a process of somatic evolution^1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing inf...

Moritz Gerstung, Clemency Jolly, Ignaty Leshchiner, Stefan C. Dentro… in Nature (2020)

Article

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

Chordomas are rare bone tumors with few therapeutic options. Here we show, using whole-exome and genome sequencing within a precision oncology program, that advanced chordomas (n = 11) may be characterized by gen...

Stefan Gröschel, Daniel Hübschmann, Francesco Raimondi… in Nature Communications (2019)

Article

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, w...

Cristina López, Kortine Kleinheinz, Sietse M. Aukema, Marius Rohde… in Nature Communications (2019)

Article

Enhancer hijacking activates oncogenic transcription factor NR4A3 in acinic cell carcinomas of the salivary glands

The molecular pathogenesis of salivary gland acinic cell carcinoma (AciCC) is poorly understood. The secretory Ca-binding phosphoprotein (SCPP) gene cluster at 4q13 encodes structurally related phosphoproteins...

Florian Haller, Matthias Bieg, Rainer Will, Cindy Körner… in Nature Communications (2019)

Article

Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer

Incomplete understanding of the metastatic process hinders personalized therapy. Here we report the most comprehensive whole-genome study of colorectal metastases vs. matched primary tumors. 65% of somatic mut...

Naveed Ishaque, Mohammed L. Abba, Christine Hauser, Nitin Patil… in Nature Communications (2018)

Article

Author Correction: The landscape of genomic alterations across childhood cancers

In this Article, author Benedikt Brors was erroneously associated with affiliation number ‘8’ (Department of Developmental Neurobiology, St Jude Children’s Research Hospital, Memphis, Tennessee, USA); the auth...

Susanne N. Gröbner, Barbara C. Worst, Joachim Weischenfeldt, Ivo Buchhalter… in Nature (2018)

Article

Genomic features of renal cell carcinoma with venous tumor thrombus

A venous tumor thrombus (VTT) is a potentially lethal complication of renal cell carcinoma (RCC) but virtually nothing is known about the underlying natural history. Based on our observation that venous thromb...

Gregor Warsow, Daniel Hübschmann, Kortine Kleinheinz… in Scientific Reports (2018)

Article

The landscape of genomic alterations across childhood cancers

Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis o...

Susanne N. Gröbner, Barbara C. Worst, Joachim Weischenfeldt, Ivo Buchhalter… in Nature (2018)

Article

Integrative genomic and transcriptomic analysis of leiomyosarcoma

Leiomyosarcoma (LMS) is an aggressive mesenchymal malignancy with few therapeutic options. The mechanisms underlying LMS development, including clinically actionable genetic vulnerabilities, are largely unknow...

Priya Chudasama, Sadaf S. Mughal, Mathijs A. Sanders… in Nature Communications (2018)

Article

The whole-genome landscape of medulloblastoma subtypes

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the develo** child, and highlight the need for molecularly targeted treatments with reduced to...

Paul A. Northcott, Ivo Buchhalter, A. Sorana Morrissy, Volker Hovestadt… in Nature (2017)