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  1. Article

    Open Access

    PRMT5 inhibition shows in vitro efficacy against H3K27M-altered diffuse midline glioma, but does not extend survival in vivo

    H3K27-altered Diffuse Midline Glioma (DMG) is a universally fatal paediatric brainstem tumour. The prevalent driver mutation H3K27M creates a unique epigenetic landscape that may also establish therapeutic vul...

    Elizabeth J. Brown, Leire Balaguer-Lluna, Adam P. Cribbs… in Scientific Reports (2024)

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    Article

    The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

    Ezh2 is a protein methylase that epigenetically modifies chromatin. Su and colleagues identify a cytoplasmic role for Ezh2 whereby it controls the extravasation of innate leukocytes through methylation of tali...

    Merry Gunawan, Nandini Venkatesan, Jia Tong Loh, Jong Fu Wong… in Nature Immunology (2015)