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Article
Open AccessDOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils
How pathogenesis of inflammatory bowel disease (IBD) depends on the complex interplay of host genetics, microbiome and the immune system is not fully understood. Here, we showed that Downstream of Kinase 3 (DO...
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Article
Open AccessHost-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection
Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected host cells activate lung ...
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Article
Open AccessEstrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution
Epidemiological studies have indicated increased risk for breast cancer within 10 years of childbirth. Acute inflammation during mammary involution has been suggested to promote this parity-associated breast c...
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Article
The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin
Ezh2 is a protein methylase that epigenetically modifies chromatin. Su and colleagues identify a cytoplasmic role for Ezh2 whereby it controls the extravasation of innate leukocytes through methylation of tali...
