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  1. Article

    Open Access

    Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells

    Metformin (MET) is increasingly implicated in reducing the incidence of multiple cancer types in patients with diabetes. However, similar effects of MET in non-diabetic women with endometrial cancer (EC) remai...

    John Mark P Pabona, Alexander F Burnett, Dustin M Brown in Reproductive Sciences (2020)

  2. No Access

    Chapter

    Maternal Metabolic State and Cancer Risk: An Evolving Manifestation of Generational Impact

    Metabolic stress in the early-life environment as a consequence of maternal overnutrition and obesity leads to an increased risk of adult metabolic syndrome in offspring. Given the greater risk for cancer deve...

    Frank A. Simmen PhD, Melissa E. Heard in Parental Obesity: Intergenerational Progra… (2016)

  3. Article

    The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein

    Breast cancer is the leading cause of cancer deaths in women. Diet and lifestyle are major contributing factors to increased breast cancer risk. While mechanisms underlying dietary protection of mammary tumor ...

    John Mark P. Pabona, Bhuvanesh Dave, Ying Su in Genes & Nutrition (2013)

  4. No Access

    Chapter

    Soy Foods: Towards the Development of Novel Therapeutics for Breast Cancer

    The increasing cognizance that diet (and lifestyle) can modify breast cancer risk and progression has motivated many breast cancer patients to take increasing personal control of the direction of their therapi...

    Rosalia C. M. Simmen, Omar M. Rahal in Cancer Chemoprevention and Treatment by Di… (2013)