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  1. Article

    Open Access

    Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS

    Enzymatic cleavage of IgG antibodies is a common strategy used by pathogenic bacteria to ablate immune effector function. The Streptococcus pyogenes bacterium secretes the protease IdeS and the glycosidase EndoS,...

    Abigail S. L. Sudol, John Butler, Dylan P. Ivory, Ivo Tews… in Nature Communications (2022)

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  2. Article

    Open Access

    Intramyocardial hemorrhage drives fatty degeneration of infarcted myocardium

    Sudden blockage of arteries supplying the heart muscle contributes to millions of heart attacks (myocardial infarction, MI) around the world. Although re-opening these arteries (reperfusion) saves MI patients ...

    Ivan Cokic, Shing Fai Chan, **ngmin Guan, Anand R. Nair… in Nature Communications (2022)

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  3. No Access

    Article

    Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4

    CD8-positive T cells are thought to play an important role in the control of infection by human immunodeficiency virus (HIV) as a result of their cytotoxic activity and by releasing soluble factors1,2. In AIDS pa...

    Georges Herbein, Ulrich Mahlknecht, Franak Batliwalla, Peter Gregersen… in Nature (1998)