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Article
Open AccessCorrection: Author Correction: Integrated genomic analyses of de novo pathways underlying atypical meningiomas
Nature Communications 8: Article number: 14433 (2017) Published online 14 February 2017; Updated 20 April 2018 In this Article, a subset of the H3K27ac ChIP-seq data (15 benign meningiomas and 2 dura samples (...
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Article
Open AccessIntegrated genomic analyses of de novo pathways underlying atypical meningiomas
Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared benign meningiomas t...
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Article
Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas
Murat Günel and colleagues identify recurrent mutations in POLR2A, which encodes the catalytic subunit of RNA polymerase II, in a subset of meningiomas. They find that POLR2A-mutant tumors can be distinguished on...
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Article
Open AccessIDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation
The single nucleotide polymorphism rs55705857, located in a non-coding but evolutionarily conserved region at 8q24.21, is strongly associated with IDH-mutant glioma development and was suggested to be a causal...
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Article
Integrated genomic characterization of IDH1-mutant glioma malignant progression
Murat Günel and colleagues use an integrated genomic approach to analyze the malignant progression of IDH1-mutant gliomas. They observe nonlinear clonal expansion of the original tumors and identify oncogenic pat...
