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  1. Article

    Open Access

    Focal adhesions contain three specialized actin nanoscale layers

    Focal adhesions (FAs) connect inner workings of cell to the extracellular matrix to control cell adhesion, migration and mechanosensing. Previous studies demonstrated that FAs contain three vertical layers, wh...

    Reena Kumari, Katharina Ven, Megan Chastney, Shrikant B. Kokate… in Nature Communications (2024)

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    Article

    Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

    The drugs currently available for Parkinson's disease patients generally treat only the symptoms, and do not prevent the degeneration and death of dopaminergic neurons in the brain, the cause the motor defects...

    Päivi Lindholm, Merja H. Voutilainen, Juha Laurén, Johan Peränen… in Nature (2007)

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    Article

    N-glycans as apical sorting signals in epithelial cells

    IN epithelial Madin–Darby canine kidney (MDCK) cells newly synthesized molecules are sorted in the trans-Golgi network and directly delivered to their apical and basolateral surface destinations1. Sorting is medi...

    Peter Scheiffele, Johan Peränen, Kai Simons in Nature (1995)