-
Article
Open AccessFocal adhesions contain three specialized actin nanoscale layers
Focal adhesions (FAs) connect inner workings of cell to the extracellular matrix to control cell adhesion, migration and mechanosensing. Previous studies demonstrated that FAs contain three vertical layers, wh...
-
Article
Open AccessTristetraprolin is a novel regulator of BDNF
Brain-derived neurotrophic factor (BDNF) regulates multiple biological processes ranging from central nervous system development and function to neuroinflammation and myogenic differentiation and repair. While...
-
Article
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo
The drugs currently available for Parkinson's disease patients generally treat only the symptoms, and do not prevent the degeneration and death of dopaminergic neurons in the brain, the cause the motor defects...
-
Article
N-glycans as apical sorting signals in epithelial cells
IN epithelial Madin–Darby canine kidney (MDCK) cells newly synthesized molecules are sorted in the trans-Golgi network and directly delivered to their apical and basolateral surface destinations1. Sorting is medi...