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Article
Ligand-dependent localization and function of ORP–VAP complexes at membrane contact sites
Oxysterol-binding protein/OSBP-related proteins (ORPs) constitute a conserved family of sterol/phospholipid-binding proteins with lipid transporter or sensor functions. We investigated the spatial occurrence a...
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Article
Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures
A previously uncharacterized member of the I-BAR subfamily of BAR-domain proteins, Pinkbar, is expressed in epithelial cells, where it stabilizes planar membrane sheets. Structural, biochemical and mutagenesis...
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Article
A molecular network for de novo generation of the apical surface and lumen
Polarized-membrane trafficking supports the delivery of polarity proteins to discrete plasma-membrane domains, although the interplay between trafficking and polarity pathways is not fully understood. The smal...